Content area

Abstract

AbstractA novel polycationic analogue of gratisin, cyclo(-Val-Orn-Leu-D-Phe-Pro-D-Lys-)2 , was designed and synthesized, which exhibited strong activity against all Gram-positive and Gram-negative bacteria tested. Its activity against Pseudomonas aeruginosa IFO 3080 was two times higher than gramicidin S.

Details

Title
A Novel Polycationic Analogue of Gratisin with Antibiotic Activity against both Gram-positive and Gram-negative Bacteria
Author
Tamaki, Makoto; Kokuno, Manabu; Suzuki, Yumiko; Iwama, Mitsuko; Shindo, Mitsuno; Uchida, Yoshiki
Pages
33-35
Publication year
2008
Publication date
Jan 2008
Publisher
Nature Publishing Group
ISSN
00218820
e-ISSN
18811469
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/ja.2008.106
ProQuest document ID
1787853101
Copyright
Copyright Nature Publishing Group Jan 2008