The first step of Fig 2 appears erroneously in the publication as a repetition of Fig 1. The correct Fig 2 should show the oxidation of cannabidiol diacetate to 9-hydroxy-cannabidiol diacetate. Please see the correct Fig 2 here.
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Fig 2. Synthesis of HUF-102(2).
Reagents and conditions: (a) SeO2, t-BuOOH, CH2Cl2, r.t; (b) DAST, CH2Cl2, 0°C.
https://doi.org/10.1371/journal.pone.0162087.g001
1. Breuer A, Haj CG, Fogaça MV, Gomes FV, Silva NR, Pedrazzi JF, et al. (2016) Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects. PLoS ONE 11(7): e0158779. pmid:27416026
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Abstract
Please see the correct Fig 2 here. thumbnail Download: * PPT PowerPoint slide * PNG larger image * TIFF original image Fig 2. (2016) Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects.
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Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer