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Abstract

After years of observing children with the rare eye cancer retinoblastoma, Alfred Knudson proposed an explanation for how two different forms of it arise. His 'two-hit' hypothesis led to the realization that the loss of gene function, not just the activation of a cancer-causing gene, could cause cancer. Knudson, who was born in Los Angeles, California, in 1922, died on 10 July, aged 93.

Details

Title
Alfred G. Knudson (1922-2016)
Author
Croce, Carlo M
Pages
397
Section
OBITUARY: COMMENT
Publication year
2016
Publication date
Aug 25, 2016
Publisher
Nature Publishing Group
ISSN
00280836
e-ISSN
14764687
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1815374851
Copyright
Copyright Nature Publishing Group Aug 25, 2016