Content area
Full Text
http://crossmark.crossref.org/dialog/?doi=10.1007/s00259-016-3552-9&domain=pdf
Web End = http://crossmark.crossref.org/dialog/?doi=10.1007/s00259-016-3552-9&domain=pdf
Web End = Eur J Nucl Med Mol Imaging (2017) 44:249258 DOI 10.1007/s00259-016-3552-9
ORIGINAL ARTICLE
Thoracic aorta calcification but not inflammationis associated with increased cardiovascular disease risk: results of the CAMONA study
Bjrn A. Blomberg1,2 & Pim A. de Jong2 & Anders Thomassen1 & Marnix G. E. Lam2 &
Werner Vach3 & Michael H. Olsen4 & Willem P. T. M. Mali2 & Jagat Narula5 &
Abass Alavi6 & Poul F. Hilund-Carlsen1,7
Received: 15 April 2016 /Accepted: 11 October 2016 /Published online: 29 October 2016 # The Author(s) 2016. This article is published with open access at Springerlink.com
AbstractPurpose Arterial inflammation and vascular calcification are regarded as early prognostic markers of cardiovascular disease (CVD). In this study we investigated the relationship between CVD risk and arterial inflammation (18F-FDG PET/CT imaging), vascular calcification metabolism (Na18F PET/CT imaging), and vascular calcium burden (CT imaging) of the thoracic aorta in a population at low CVD risk.
Methods Study participants underwent blood pressure measurements, blood analyses, and 18F-FDG and Na18F PET/CT imaging. In addition, the 10-year risk for development of CVD, based on the Framingham risk score (FRS), was
estimated. CVD risk was compared across quartiles of thoracic aorta 18F-FDG uptake, Na18F uptake, and calcium burden on CT.
Results A total of 139 subjects (52 % men, mean age 49 years, age range 21 75 years, median FRS 6 %) were evaluated. CVD risk was, on average, 3.7 times higher among subjects with thoracic aorta Na18F uptake in the highest quartile compared with those in the lowest quartile of the distribution(15.5 % vs. 4.2 %; P < 0.001). CVD risk was on average,3.7 times higher among subjects with a thoracic aorta calcium burden on CT in the highest quartile compared with those in the lowest two quartiles of the distribution (18.0 % vs. 4.9 %; P < 0.001). CVD risk was similar in subjects in all quartiles of thoracic aorta 18F-FDG uptake.
Conclusion Our findings indicate that an unfavourable CVD risk profile is associated with marked increases in vascular calcification metabolism and vascular calcium burden of the thoracic aorta, but not with arterial inflammation.
Keywords PET/CT . [18F]Fluorodeoxyglucose (18F-FDG) . [18F]Sodium fluoride (Na18F) . Arterial inflammation . Vascular calcification . Atherosclerosis
Introduction
Adverse cardiovascular events...