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Rational: Acute lung injury is associated with increased morbidity and mortality in the elderly (>65 years of age). However, the effects of age on pulmonary inflammation, structure and function in acute lung injury have been understudied. In the present study, we investigated age-dependent features of acute lung injury in young and old mice.
Methods: Young (2-3 months) and old (18-19 months) male C57BL/6 mice were intranasally dosed with 2.5 mg lipopolysaccharide (LPS)/kg body weight (LPS-treated animals; n=10 per age group) or saline (control animals; n=7 per age group). Twenty-four hours later, pulmonary function was assessed with a rodent FlexiVent and...