Content area
Abstract
Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.
Details
Title
CPEB4 links the clock and the UPR to protect the liver
Author
Moore, Paul C; Oakes, Scott A
Pages
79-81
Publication year
2017
Publication date
Feb 2017
ISSN
14657392
e-ISSN
14764679
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1869210551
Copyright
Copyright Nature Publishing Group Feb 2017