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Intensive Care Med (2017) 43:304377 DOI 10.1007/s00134-017-4683-6
Surviving Sepsis Campaign: International Guidelines forManagement ofSepsis andSeptic Shock: 2016
Andrew Rhodes1*, Laura E. Evans2, Waleed Alhazzani3, Mitchell M. Levy4, Massimo Antonelli5, Ricard Ferrer6, Anand Kumar7, Jonathan E. Sevransky8, Charles L. Sprung9, Mark E. Nunnally2, Bram Rochwerg3,Gordon D. Rubenfeld10, Derek C. Angus11, Djillali Annane12, Richard J. Beale13, Georey J. Bellinghan14, Gordon R. Bernard15, JeanDaniel Chiche16, Craig Coopersmith8, Daniel P. De Backer17, Craig J. French18, Seitaro Fujishima19, Herwig Gerlach20, Jorge Luis Hidalgo21, Steven M. Hollenberg22, Alan E. Jones23,Dilip R. Karnad24, Ruth M. Kleinpell25, Younsuk Koh26, Thiago Costa Lisboa27, Flavia R. Machado28,John J. Marini29, John C. Marshall30, John E. Mazuski31, Lauralyn A. McIntyre32, Anthony S. McLean33, Sangeeta Mehta34, Rui P. Moreno35, John Myburgh36, Paolo Navalesi37, Osamu Nishida38, Tiany M. Osborn31, Anders Perner39, Colleen M. Plunkett25, Marco Ranieri40, Christa A. Schorr22, Maureen A. Seckel41, Christopher W. Seymour42, Lisa Shieh43, Khalid A. Shukri44, Steven Q. Simpson45, Mervyn Singer46, B. Taylor Thompson47, Sean R. Townsend48, Thomas Van der Poll49, JeanLouis Vincent50, W. Joost Wiersinga49, Janice L. Zimmerman51 and R. Phillip Dellinger22
2017 SCCM and ESICM
*Correspondence: [email protected]
1 St. Georges Hospital, London, England, UKFull author information is available at the end of the article
This article is being simultaneously published in Critical Care Medicine (DOI: http://dx.doi.org/10.1097/CCM.0000000000002255
Web End =10.1097/CCM.0000000000002255 ) and Intensive Care Medicine.
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INTRODUCTION
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection [13]. Sepsis and septic shock are major healthcare problems, aecting millions of people around the world each year, and killing as many as one in four (and often more) [46]. Similar to polytrauma, acute myocardial infarction, or stroke, early identication and appropriate management in the initial hours after sepsis develops improves outcomes.
The recommendations in this document are intended to provide guidance for the clinician caring for adult patients with sepsis or septic shock. Recommendations from these guidelines cannot replace the clinicians decision-making capability when presented with a patients unique set of clinical variables. These guidelines are appropriate for the sepsis patient in a hospital setting. These guidelines are intended to be best practice (the committee considers this a goal for clinical practice) and not created to represent standard of care.
METHODOLOGY
Below is a summary of the important methodologic considerations for developing these...