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ABSTRACT
Objective: The co-stimulatory molecule B7-H3 plays an important role in prognosis of several malignancies. However, its prognostic value in clinic in patient with colorectal cancer (CRC) is still controversial. This meta-analysis evaluated the relationship between B7-H3 expression and the outcomes of CRC patients. Methods: PubMed, Google Scholar, Embase, CNKI and Wanfang database were searched for the studies on the relationship between the expression of B7-H3 and prognosis of CRC patients. Pooled odds ratios (ORs) analysis with 95% confidence interval (95% CIs) for lymph node metastasis, 24-month overall survival and 72-month overall survival were performed mainly using Review Manager 5.0.
Results: Six articles including 1,202 total CRC cases were included for the meta-analysis. Pooled analysis with fixed-effects model showed that B7-H3 expression had no relationship with lymphatic metastasis in CRC patients (Fixed-effects, OR= 1.18; 95 % CI:0.87-1.61, P=0.28). However, B7H3 expression was associated with 24-month overall survival (Fixed-effects, OR=0.48, 95% CI: 0.32-0.74, P<0.001) and 72-month overall survival (Fixed-effects, OR = 0.61, 95% CI: 0.43-0.85, P< 0.01) in CRC patients.
Conclusion: The co-stimulatory molecule B7-H3 expression is negatively associated with lymph node metastasis in CRC. However, B7-H3 detection might be a feasible and effective means to predict the prognosis in CRC patients.
KEY WORDS: B7-H3, Colorectal cancer, Meta-analysis, Prognosis.
doi: https://doi.org/10.12669/pjms.326.11511
INTRODUCTION
Colorectal cancer (CRC) is the fourth most common malignancy leading to death globally, and accounts for about 600,000 deaths every year in the world.1 The countries of Europe, Oceania and North America are reported to have the higher morbidity, whereas some countries of Asia and Africa have comparatively lower morbidity.2 The prognosis of CRC patients has steadily increased during the past 10 years in most of countries. Five year survival has reached nearly 65% in high-income countries, such as the USA, European countries and Australia, but remains less than 50% in low-income countries.3
Lymph node Meta stasis is an important pathway of CRC cancer systemic metastasis, and is closely related to the prognosis of CRC patients.4 Frequently, regional lymph nodes are initial metastasis sites, and then tumor cells migrate into the lymph nodes.5,6 B7-H3 was first identified in 2001, is an immune-regulatory protein in B7 family of T cell co-stimulatory molecules, which may be a new prognostic marker.7,8 2IgB7-H3 and 4IgB7-H3 are...