Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke

Male

412

(66.0)

412

(66.0)

Body-mass index (kg/m2)

25.0?±?3.9

24.6?±?3.1

0.0212

Waist-hip ratio

0.94?±?0.08

0.87?±?0.07

<0.0001

Cigarette smoking/alcohol consumption

Never/Never

296

(47.6)

408

(65.8)

<0.0001

Either one

203

(32.6)

177

(28.6)

Ever/Ever

123

(19.8)

35

(5.7)

Hypertension

482

(77.2)

371

(59.5)

<0.0001

Diabetes mellitus

300

(48.1)

105

(16.8)

<0.0001

Heart disease

163

(26.1)

109

(17.5)

0.0002

Dyslipidemia

476

(76.5)

504

(80.8)

0.0677

Family stroke history

149

(23.9)

97

(15.5)

0.0008

Estradiol levela

Female

155

2.90 (0.97)

128

1.68 (1.36)

<0.0001

Male

358

3.18 (0.54)

255

2.97 (0.57)

<0.0001

Data are presented as n (%) or mean?±?standard deviation

aEstradiol level was shown in log transformed value

Association between inflammatory genes and ischemic stroke risk

Genotype frequencies of MCP-1 (rs1024611 and rs3760396), CCR2 (rs1799864 and rs1799865), and E-selectin (rs2076059, rs10800469, rs3917412, and rs5368) are depicted in Table 2. These SNPs were all under HWE. There were no prominent associations between SNPs on MCP-1, CCR2, or E-selectin genes in addition to rs2076059, which was located on E-selectin and significantly increased the risk of ischemic stroke under the dominant model (Table 2). [ Table Omitted - see PDF ]

Table 2

Association between inflammatory genes and the risk of ischemic stroke

Gene

SNP ID

Allele risk/

References

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