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Copyright Nature Publishing Group May 2017

Abstract

The germline mutation rate has been extensively studied and has been found to vary greatly between species, but much less is known about the somatic mutation rate in multicellular organisms, which remains very difficult to determine. Here, we present data on somatic mutation rates in mice and humans, obtained by sequencing single cells and clones derived from primary fibroblasts, which allows us to make the first direct comparison with germline mutation rates in these two species. The results indicate that the somatic mutation rate is almost two orders of magnitude higher than the germline mutation rate and that both mutation rates are significantly higher in mice than in humans. Our findings demonstrate both the privileged status of germline genome integrity and species-specific differences in genome maintenance.

Details

Title
Differences between germline and somatic mutation rates in humans and mice
Author
Milholland, Brandon; Dong, Xiao; Zhang, Lei; Hao, Xiaoxiao; Suh, Yousin; Vijg, Jan
Pages
15183
Publication year
2017
Publication date
May 2017
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1896368713
Copyright
Copyright Nature Publishing Group May 2017