Content area
Full Text
About the Authors:
Gergès Rizkallah
Affiliations International Center for Research in Infectiology, Retroviral Oncogenesis laboratory, INSERM U1111 -Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France, Equipe labellisée “Ligue Nationale Contre le Cancer”, Lyon, France
ORCID http://orcid.org/0000-0003-2608-8963
Sandrine Alais
Affiliations International Center for Research in Infectiology, Retroviral Oncogenesis laboratory, INSERM U1111 -Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France, Equipe labellisée “Ligue Nationale Contre le Cancer”, Lyon, France
Nicolas Futsch
Affiliations International Center for Research in Infectiology, Retroviral Oncogenesis laboratory, INSERM U1111 -Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France, Equipe labellisée “Ligue Nationale Contre le Cancer”, Lyon, France
ORCID http://orcid.org/0000-0003-2505-5000
Yuetsu Tanaka
Affiliation: Department of Immunology, Graduate School of Medicine, University of the Ryukyus, Uehara 207, Nishihara-cho, Okinawa, Japan
Chloé Journo
Affiliations International Center for Research in Infectiology, Retroviral Oncogenesis laboratory, INSERM U1111 -Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France, Equipe labellisée “Ligue Nationale Contre le Cancer”, Lyon, France
Renaud Mahieux
Affiliations International Center for Research in Infectiology, Retroviral Oncogenesis laboratory, INSERM U1111 -Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France, Equipe labellisée “Ligue Nationale Contre le Cancer”, Lyon, France
Hélène Dutartre
* E-mail: [email protected]
Affiliations International Center for Research in Infectiology, Retroviral Oncogenesis laboratory, INSERM U1111 -Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, Lyon, France, Equipe labellisée “Ligue Nationale Contre le Cancer”, Lyon, FranceAbstract
Human T lymphotropic Virus type 1 (HTLV-1) is the etiological agent of Adult T cell Leukemia/Lymphoma (ATLL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Both CD4+ T-cells and dendritic cells (DCs) infected with HTLV-1 are found in peripheral blood from HTLV-1 carriers. We previously demonstrated that monocyte-derived IL-4 DCs are more susceptible to HTLV-1 infection than autologous primary T-cells, suggesting that DC infection precedes T-cell infection. However, during blood transmission, breast-feeding or sexual transmission, HTLV-1 may encounter different DC subsets present in the blood, the intestinal or genital mucosa respectively. These different contacts may impact HTLV-1 ability to infect DCs and its subsequent transfer to T-cells. Using in vitro monocyte-derived IL-4 DCs, TGF-[Beta]...