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Molecular Psychiatry (2017) 22, 900909
http://www.nature.com/mp
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L Schmaal1, DP Hibar2, PG Smann3, GB Hall4, BT Baune5, N Jahanshad2, JW Cheung2, TGM van Erp6, D Bos7,8, MA Ikram7,8,9,MW Vernooij7,8, WJ Niessen7,10,11, H Tiemeier8,12, A Hofman8, K Wittfeld13, HJ Grabe13,14, D Janowitz14, R Blow15, M Selonke14,H Vlzke16,17,18, D Grotegerd19, U Dannlowski19,20, V Arolt19, N Opel19, W Heindel21, H Kugel21, D Hoehn3, M Czisch3,B Couvy-Duchesne22,23,24, ME Rentera24, LT Strike22, MJ Wright22,23, NT Mills22,24, GI de Zubicaray25, KL McMahon23, SE Medland24,
NG Martin24, NA Gillespie26, R Goya-Maldonado27, O Gruber28, B Krmer28, SN Hatton29, J Lagopoulos29, IB Hickie29, T Frodl30,31,A Carballedo31, EM Frey32, LS van Velzen1, BWJH Penninx1, M-J van Tol33, NJ van der Wee34, CG Davey35,36,37, BJ Harrison37, B Mwangi38, B Cao38, JC Soares38, IM Veer39, H Walter39, D Schoepf40, B Zurowski41, C Konrad20,42, E Schramm43, C Normann43, K Schnell28,MD Sacchet44, IH Gotlib44, GM MacQueen45, BR Godlewska46, T Nickson47, AM McIntosh47,48, M Papmeyer47,49, HC Whalley47, J Hall47,50, JE Sussmann47,51, M Li52, M Walter52,53, L Aftanas54, I Brack54, NA Bokhan55,56,57, PM Thompson2 and DJ Veltman1 for the ENIGMA-Major Depressive Disorder Working Group58
The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents.
1Department of Psychiatry and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands; 2Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA; 3Neuroimaging Core Unit, Max Planck Institute of Psychiatry, Munich, Germany;
4Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada; 5Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia;
6Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA; 7Department of Radiology, Erasmus MC University Medical Center, Rotterdam,...