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About the Authors:
Nutabi Camargo
Contributed equally to this work with: Nutabi Camargo, Andrea Goudriaan
Affiliation: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands
Andrea Goudriaan
Contributed equally to this work with: Nutabi Camargo, Andrea Goudriaan
Affiliation: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands
Anne-Lieke F. van Deijk
Affiliation: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands
Willem M. Otte
Affiliations Biomedical MR Imaging and Spectroscopy group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, the Netherlands, Department of Pediatric Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands
Jos F. Brouwers
Affiliation: Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, the Netherlands
Hans Lodder
Affiliation: Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands
David H. Gutmann
Affiliation: Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Klaus-Armin Nave
Affiliation: Max-Planck-Institute of Experimental Medicine, Department of Neurogenetics, Goettingen, Germany
Rick M. Dijkhuizen
Affiliation: Biomedical MR Imaging and Spectroscopy group, Center for Image Sciences, University Medical Center Utrecht, Utrecht, the Netherlands
ORCID http://orcid.org/0000-0002-4623-4078
Huibert D. Mansvelder
Affiliation: Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands
Roman Chrast
Affiliation: Department of Neuroscience and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
August B. Smit
Affiliation: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the Netherlands
Mark H. G. Verheijen
* E-mail: [email protected]
Affiliation: Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, the NetherlandsAbstract
In the vertebrate nervous system, myelination of axons for rapid impulse propagation requires the synthesis of large amounts of lipids and proteins by oligodendrocytes and Schwann cells. Myelin membranes are thought to be cell-autonomously assembled by these axon-associated glial cells. Here, we report the surprising finding that in normal brain development, a substantial fraction of the lipids incorporated into central nervous system (CNS)...