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Abstract:
In the present study, a new series of Methyl -4-(benzo[d]thiazol-2yl) phenylcarbamodithioate amine derived from Methyl -4(benzo[d]thiazol-2yl) phenylcarbamodithioate (4TT1-TT6) have been synthesized by reaction of the thio methyl group with different amines in presence of ethanol. The structural assessment of the compounds (TT1- TT6) was made on the basis of spectral data. The synthesized compounds were screened for their in vitro growth inhibiting activity against strains of bacteria and fungi viz., Bacillus subtilis and Candida albicans were compared with standard agents such as Norfloxacin and Fluconazole using well plate method. Compounds exhibit moderate to high antibacterial and antifungal activity.
Keywords: Antimicrobial activity, Benzothiazole, Heterocyclic, Synthesis, Thiourea.
Introduction
The chemistry of thioureas and their derivatives has attracted a lot of attention due to their interesting physicochemical properties. The synthetic ease of thioureas, and use of inexpensive chemicals and reagents in synthesis and their wide range of pharmaceutical application has made them potential moiety for designing of new compounds. The modification that may be done on either nitrogen atoms of thiourea enhances the physical and chemical properties and their biological activities. Benzothiazole derivatives widely used in pharmaceutical industry [1], medicinal chemistry and drug development. Derivatives of benzothiazole have numerous biological activities such as antimicrobial [2-3], antibacterial [4], antifungal [5], anticancer [6], anti-inflammatory [7], anticonvulsant [8], antidiabetic [9], antipsychotic [10], protein tyrosine inhibitor [11] and diuretic [12], properties. Nitrogen-containing heterocyclic systems have a diverse spectrum of pharmacological properties. Different heterocyclic motifs can be incorporated to produce molecules with enhanced biological properties. A review of the literature suggests that there is the scope for the design of additional benzothiazole derivatives with antimicrobial activity, by examining the effect of a number of different functional groups. Thiocarbamide, thiourea derivatives have biological activity such as antibacterial [13-14] antimicrobial [15] antioxidant [16] anti HIV [17-18] anti malarial [19] and anticancer [20]. The review of benzothiazole and thiourea motivate to synthesize such derivatives.
Materials And Methods
The identification and purity of the products was checked by TLC with different combination and strength of mobile phases, i.e. hexane: ethyl acetate (2:6) or methanol: chloroform (1:8) using iodine vapour and UV light as detecting agents. Melting points were taken in open capillaries in an electric melting point apparatus and are uncorrected. The 1H NMR spectra...