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About the Authors:
Christian Lundtoft
Contributed equally to this work with: Christian Lundtoft, Anthony Afum-Adjei Awuah, Jens Rimpler
Affiliation: Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Duesseldorf, Germany
Anthony Afum-Adjei Awuah
Contributed equally to this work with: Christian Lundtoft, Anthony Afum-Adjei Awuah, Jens Rimpler
Affiliations Kumasi Centre for collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana, School of Medical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
Jens Rimpler
Contributed equally to this work with: Christian Lundtoft, Anthony Afum-Adjei Awuah, Jens Rimpler
Affiliation: Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Duesseldorf, Germany
Kirstin Harling
Affiliation: Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Duesseldorf, Germany
Norman Nausch
Affiliation: Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Duesseldorf, Germany
ORCID http://orcid.org/0000-0002-9704-2148
Malte Kohns
Affiliation: Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Duesseldorf, Germany
Ernest Adankwah
Affiliation: Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Duesseldorf, Germany
Franziska Lang
Affiliation: Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Duesseldorf, Germany
ORCID http://orcid.org/0000-0001-6398-3436
Laura Olbrich
Affiliation: Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Duesseldorf, Germany
Ertan Mayatepek
Affiliation: Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Duesseldorf, Germany
ORCID http://orcid.org/0000-0001-8460-3738
Ellis Owusu-Dabo
Affiliations Kumasi Centre for collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana, School of Medical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana
Marc Jacobsen
* E-mail: [email protected]
Affiliation: Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children’s Hospital, Medical Faculty, Duesseldorf, Germany
ORCID http://orcid.org/0000-0002-4703-5652Abstract
T-cell proliferation and generation of protective memory during chronic infections depend on Interleukin-7 (IL-7) availability and receptivity. Regulation of IL-7 receptor (IL-7R) expression and signalling are key for IL-7-modulated T-cell functions. Aberrant expression of soluble (s) and membrane-associated (m) IL-7R molecules is associated with development of autoimmunity and immune failure in acquired immune deficiency syndrome (AIDS) patients. Here we investigated the role of IL-7/IL-7R on T-cell immunity in human tuberculosis. We performed two independent case-control studies comparing tuberculosis patients and healthy contacts. This was combined...