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Background
Asthma is a chronic inflammatory airway disorder and affects millions of people worldwide. Most asthma is mild to moderate and responds well to standard therapies, including glucocorticoid, ß2-agonist and leukotriene modifiers. However, 5-10% of asthma patients have severe symptoms that do not respond sufficiently to these therapies. Recent studies showed that oxidative stress might be one of the important contributing factors in severe asthma. The aim of the study was to investigate the role of nuclear factor E2-related factor 2 (Nrf2), a pivotal regulator of...