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Abstract
Background
There are many studies about the association of β fibrinogen gene G-455A polymorphism and the risk of coronary heart disease (CHD). However, the results of these studies are inconsistent.
Objective
This study aimed to investigate the association of β fibrinogen gene G-455A polymorphism with the risk of CHD using meta analysis. This study was limited to the Asian population.
Methods
Published studies from PubMed, Embase, and CNKI databases (up to December 20th, 2015) were searched for eligible publications. The following information was extracted from each study: (1) name of first author; (2) year of publication; (3) country of origin; (4) sample size of cases and controls, and (5) size of each allele. The combined odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between β fibrinogen gene G-455A polymorphism and the risk of CHD were assessed using random or fixed effect model. A comprehensive meta analysis (CMA) 2.0 was used to analyze the data.
Results
Nineteen studies (4011 cases/3673 controls) regarding the association of β fibrinogen gene G-455A polymorphism and the risk of CHD were included in this meta analysis. The results indicated that β fibrinogen gene G-455A polymorphism was associated with increased (A vs. G: OR 95% CI=1.42 [1.19-1.70],p<0.001; AA vs. GG+GA: OR 95% CI=1.60 [1.13-2.26],p=0.008; GA vs. GG+AA: OR 95% CI=1.30 [1.07-1.58],p=0.008) and decreased the risk of CHD (G vs. A: OR 95% CI=0.70 [0.59-0.84],p<0.001; GG vs. GA+AA: OR 95% CI=0.68 [0.55-0.84],p<0.001).
Conclusions
In the Asian population, the β fibrinogen gene G-455A polymorphism was associated with the risk of CHD.