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About the Authors:
Michal Bassani-Sternberg
Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Writing - original draft, Writing - review & editing
* E-mail: [email protected] (DG); [email protected] (MBS)
¶‡ These authors share first authorship on this work.
Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland
ORCID http://orcid.org/0000-0002-1934-954X
Chloé Chong
Roles Formal analysis, Investigation, Methodology
Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland
Philippe Guillaume
Roles Formal analysis, Investigation, Methodology, Resources
Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland
Marthe Solleder
Roles Formal analysis, Investigation, Methodology
Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland
HuiSong Pak
Roles Investigation, Methodology
Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland
Philippe O. Gannon
Roles Resources
Affiliation: Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland
ORCID http://orcid.org/0000-0003-3263-3999
Lana E. Kandalaft
Roles Resources
Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland
George Coukos
Roles Funding acquisition, Resources
Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland
David Gfeller
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
* E-mail: [email protected] (DG); [email protected] (MBS)
¶‡ These authors share first authorship on this work.
Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland
ORCID http://orcid.org/0000-0002-3952-0930Abstract
The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a central role in our ability to understand and predict (neo-)antigen presentation in infectious diseases and cancer. Here, by exploiting co-occurrence of HLA-I alleles across ten newly generated as well as forty public HLA peptidomics datasets comprising more than 115,000 unique peptides, we show that we can rapidly and accurately identify...