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Received Feb 21, 2017; Accepted Aug 2, 2017
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1. General Background
Enteric fever is a severe systemic and febrile illness, caused by
Antimicrobial agents have long been used to treat the enteric fever and also to reduce mortality associated with severe cases [4]. Traditional antimicrobial regimens previously used for the treatment of enteric fever were chloramphenicol, ampicillin, and trimethoprim-sulfamethoxazole. However the emergence of multidrug resistant (MDR)
In Nepal, there is continuous change in the epidemiology of enteric fever during the last few decades [10]. Series of enteric fever outbreaks linked to variable drug susceptibilities have been reported since the first report of MDR