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Abstract
Premna tomentosa is a plant with various medicinal roles. The present study deals with the Gas Chromatography Mass Spectroscopy analysis of Premna tomentosa. This plant is reported to have medicinal activities such as anti-inflammatory, anti-nociceptive, hypnotic, cytoprotective, immunomodulatory, hepatoprotective, antibacterial, antiulcer, antibiotic and anti oxidant etc. The GC MS results indicated the presence of some important bio molecules like Copaen, alpha-Amyrin, betaSitosterol, Pentacosane, Acetic acid, 3-hydroxy-4,4,10,13-tetramethyl-7-oxo-2,3,4,7,8,9,10,ll,12,13,14,15,16,17tetradecahydro-lH-cyclopenta[a]phe, Hentriacontane, Hexadecanoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester and Caryophyllene which have known medicinal values similar to the medicinal roles as found in the plant. The results are one step further in understanding the molecular mechanism of action of this medicinal plant.
Key words-Premna tomentosa, GC MS, Anti-inflammatory, Anti-nociceptive, Copaen, Alpha-Amyrin
Introduction
Plants are utilized as therapeutic agents since time immemorial in both organized (Ayurveda, Sidhha and Unani) and unorganized (folk, tribal, native) forms of traditional medicine. With the increasing acceptance of herbal medicine as an alternative form of health care, the screening of medicinal plants for active compounds has become very interesting to understand the novel mechanism of action [1, 2, 3]. Investigations of plants used in traditional and modern medicine is a source of inspiration and as models for the synthesis of new drugs with better therapeutic, chemical or physical properties than the original compounds [4].
There are numerous reports on the GC MS analysis studies on many plants and plant parts. These studies were undertaken to ascertain the presence of active bio molecules which have therapeutic activities [5, 6].
The present study deals with the GC MS analysis of a medicinal plant Premna tomentosa which is known as an important medicinal plant. The Plant was collected and identified by a reputed botanist in Chennai. Jamel et al, 2015, have elaborately discussed about the medicinal aspects of Premna in their review [7]. The bark of this plant is used for diarrhea. The dried plant paste is uses to skin protection. Leaves are good medicine for dropsy and also used to treat sores. The decoction of roots and leaves are used as tonic after childbirth. The anti-inflammatory activity of Premna leaves was reported by Alam et al, 1993 [8]. The leaves are reported to be anti-nociceptive, hypnotic, immune-modulatory (Devi et al, 2003), hepatoprotective (Devi et al, 2004), antimicrobial and...