Details
Title
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
Author
Bowl, Michael R 1 ; Simon, Michelle M 1 ; Ingham, Neil J 2 ; Greenaway, Simon 1 ; Santos, Luis 1 ; Cater, Heather 1 ; Taylor, Sarah 1 ; Mason, Jeremy 3
; Kurbatova, Natalja 3 ; Pearson, Selina 4 ; Bower, Lynette R 5 ; Clary, Dave A 5 ; Meziane, Hamid 6 ; Reilly, Patrick 6 ; Minowa, Osamu 7 ; Kelsey, Lois 8 ; Allen, Sue 1 ; Clementson-Mobbs, Sharon 1 ; Codner, Gemma 1 ; Fray, Martin 1 ; Gardiner, Wendy 1 ; Joynson, Russell 1 ; Kenyon, Janet 1 ; Loeffler, Jorik 1 ; Nell, Barbara 1 ; Parker, Andrew 1 ; Deen Quwailid 1 ; Stewart, Michelle 1 ; Walling, Alison 1 ; Zaman, Rumana 1 ; Chao-Kung, Chen 3 ; Conte, Nathalie 3 ; Matthews, Peter 3 ; Relac, Mike 3 ; Tudose, Ilinca 3 ; Warren, Jonathan 3 ; Elise Le Marchand 6 ; Amal El Amri 6 ; Leila El Fertak 6 ; Ennah, Hamid 6 ; Ali-Hadji, Dalila 6 ; Ayadi, Abdel 6 ; Wattenhofer-Donze, Marie 6 ; Moulaert, David 6 ; Jacquot, Sylvie 6 ; André, Philippe 6 ; Marie-Christine Birling 6 ; Pavlovic, Guillaume 6 ; Lalanne, Valérie 6 ; Lux, Aline 6 ; Riet, Fabrice 6 ; Mittelhaeuser, Christophe 6 ; Bour, Raphael 6 ; Guimond, Alain 6 ; Chaouki Bam’Hamed 6 ; Leblanc, Sophie 6 ; Vasseur, Laurent 6 ; Selloum, Mohammed 6 ; Sorg, Tania 6 ; Ayabe, Shinya 7 ; Furuse, Tamio 7 ; Kaneda, Hideki 7 ; Kobayashi, Kimio 7 ; Masuya, Hiroshi 7 ; Miura, Ikuo 7 ; Obata, Yuichi 7 ; Suzuki, Tomohiro 7 ; Tamura, Masaru 7 ; Tanaka, Nobuhiko 7 ; Yamada, Ikuko 7 ; Yoshiki, Atsushi 7 ; Berberovic, Zorana 8 ; Bubshait, Mohammed 8 ; Cabezas, Jorge 8 ; Carroll, Tracy 8 ; Clark, Greg 8 ; Clarke, Shannon 8 ; Creighton, Amie 8 ; Danisment, Ozge 8 ; Eskandarian, Mohammad 8 ; Feugas, Patricia 8 ; Gertsenstein, Marina 8 ; Guo, Ruolin 8 ; Hunter, Jane 8 ; Jacob, Elsa 8 ; Lan, Qing 8 ; Laurin, Valerie 8 ; Law, Napoleon 8 ; MacMaster, Sue 8 ; Miller, David 8 ; Morikawa, Lily 8 ; Newbigging, Susan 8 ; Owen, Celeste 8 ; Penton, Patricia 8 ; Pereira, Monica 8 ; Qu, Dawei 8 ; Shang, Xueyuan 8 ; Sleep, Gillian 8 ; Khondoker Sohel 8 ; Tondat, Sandra 8 ; Wang, Yanchun 8 ; Vukobradovic, Igor 8 ; Zhu, Yingchun 8 ; Chiani, Francesco 9 ; Chiara Di Pietro 9 ; Gianfranco Di Segni 9 ; Ermakova, Olga 9 ; Ferrara, Filomena 9 ; Fruscoloni, Paolo 9 ; Gambadoro, Aalessia 9 ; Gastaldi, Serena 9 ; Golini, Elisabetta 9 ; Gina La Sala 9 ; Mandillo, Silvia 9 ; Marazziti, Daniela 9 ; Massimi, Marzia 9 ; Matteoni, Rafaele 9 ; Orsini, Tiziana 9 ; Pasquini, Miriam 9 ; Raspa, Marcello 9 ; Rauch, Aline 9 ; Rossi, Gianfranco 9 ; Rossi, Nicoletta 9 ; Putti, Sabrina 9 ; Scavizzi, Ferdinando 9 ; Tocchini-Valentini, Giuseppe D 9 ; Beig, Joachim 10 ; Bürger, Antje 10 ; Giesert, Florian 10 ; Graw, Jochen 10 ; Kühn, Ralf 10 ; Oritz, Oskar 10 ; Schick, Joel 10 ; Seisenberger, Claudia 10 ; Amarie, Oana 11 ; Garrett, Lillian 11 ; Hölter, Sabine M 11 ; Zimprich, Annemarie 11 ; Aguilar-Pimentel, Antonio 12 ; Beckers, Johannes 12 ; Brommage, Robert 12 ; Calzada-Wack, Julia 12 ; Fuchs, Helmut 12 ; Gailus-Durner, Valérie 12 ; Lengger, Christoph 12 ; Leuchtenberger, Stefanie 12 ; Maier, Holger 12 ; Marschall, Susan 12 ; Moreth, Kristin 12 ; Neff, Frauke 12 ; Östereicher, Manuela A 12 ; Rozman, Jan 12 ; Steinkamp, Ralph 12 ; Stoeger, Claudia 12 ; Treise, Irina 12 ; Stoeger, Tobias 13 ; Ali Önder Yildrim 13 ; Eickelberg, Oliver 14 ; Becker, Lore 15 ; Klopstock, Thomas 16 ; Ollert, Markus 17 ; Busch, Dirk H 18 ; Schmidt-Weber, Carsten 19 ; Bekeredjian, Raffi 20 ; Zimmer, Andreas 21 ; Rathkolb, Birgit 22 ; Wolf, Eckhard 23 ; Klingenspor, Martin 24 ; Tocchini-Valentini, Glauco P 9 ; Gao, Xiang 25 ; Bradley, Allan 4 ; Skarnes, William C 4 ; Moore, Mark 26 ; Beaudet, Arthur L 27 ; Justice, Monica J 28 ; Seavitt, John 27 ; Dickinson, Mary E 29 ; Wurst, Wolfgang 10 ; Martin Hrabe de Angelis 12
; Herault, Yann 30
; Wakana, Shigeharu 7
; Nutter, Lauryl M J 8 ; Flenniken, Ann M 8 ; McKerlie, Colin 8
; Murray, Stephen A 31 ; Svenson, Karen L 31 ; Braun, Robert E 31 ; West, David B 32 ; Lloyd, K C Kent 5
; Adams, David J 4 ; White, Jacqui 4 ; Karp, Natasha 4 ; Flicek, Paul 3
; Smedley, Damian 33
; Meehan, Terrence F 3 ; Parkinson, Helen E 3 ; Teboul, Lydia M 1 ; Wells, Sara 1 ; Steel, Karen P 2 ; Mallon, Ann-Marie 1 ; Brown, Steve D M 1
1 Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, UK
2 King’s College London, London, UK; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
3 European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
5 Mouse Biology Program, University of California, Davis, California, USA
6 CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), Illkirch-Graffenstaden, France
7 RIKEN BioResource Center, Tsukuba, Ibaraki, Japan
8 The Centre for Phenogenomics, Toronto, Ontario, Canada; The Hospital for Sick Children, Toronto, Ontario, Canada; Canada and Mount Sinai Hospital, Toronto, Ontario, Canada
9 Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo, Italy
10 Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany
11 Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany
12 German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany
13 German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Center for Lung Research, Gießen, Germany
14 Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Center for Lung Research, Gießen, Germany
15 German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany; Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, Munich, Germany
16 Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, Munich, Germany
17 Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg; Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis, University of Southern Denmark, Odense, Denmark
18 Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
19 Center of Allergy & Environment (ZAUM), Technische Universität München, and Helmholtz Zentrum München, Ingolstaedter Landstrasse, Neuherberg, Germany
20 Department of Cardiology, University of Heidelberg, Heidelberg, Germany
21 Institute of Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany
22 German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany; Ludwig-Maximilians-Universität München, Gene Center, Institute of Molecular Animal Breeding and Biotechnology, Munich, Germany
23 Ludwig-Maximilians-Universität München, Gene Center, Institute of Molecular Animal Breeding and Biotechnology, Munich, Germany
24 Institute for Food and Health, Technical University Munich, Freising-Weihenstephan, Germany
25 SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China
26 IMPC, San Anselmo, California, USA
27 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
28 The Centre for Phenogenomics, Toronto, Ontario, Canada; The Hospital for Sick Children, Toronto, Ontario, Canada; Canada and Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
29 Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
30 CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), Illkirch-Graffenstaden, France; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, Illkirch, France
31 The Jackson Laboratory, Bar Harbor, Maine, USA
32 Childrens’ Hospital Oakland Research Institute, Oakland, California, USA
33 Queen Mary University of London, London, UK
; Kurbatova, Natalja 3 ; Pearson, Selina 4 ; Bower, Lynette R 5 ; Clary, Dave A 5 ; Meziane, Hamid 6 ; Reilly, Patrick 6 ; Minowa, Osamu 7 ; Kelsey, Lois 8 ; Allen, Sue 1 ; Clementson-Mobbs, Sharon 1 ; Codner, Gemma 1 ; Fray, Martin 1 ; Gardiner, Wendy 1 ; Joynson, Russell 1 ; Kenyon, Janet 1 ; Loeffler, Jorik 1 ; Nell, Barbara 1 ; Parker, Andrew 1 ; Deen Quwailid 1 ; Stewart, Michelle 1 ; Walling, Alison 1 ; Zaman, Rumana 1 ; Chao-Kung, Chen 3 ; Conte, Nathalie 3 ; Matthews, Peter 3 ; Relac, Mike 3 ; Tudose, Ilinca 3 ; Warren, Jonathan 3 ; Elise Le Marchand 6 ; Amal El Amri 6 ; Leila El Fertak 6 ; Ennah, Hamid 6 ; Ali-Hadji, Dalila 6 ; Ayadi, Abdel 6 ; Wattenhofer-Donze, Marie 6 ; Moulaert, David 6 ; Jacquot, Sylvie 6 ; André, Philippe 6 ; Marie-Christine Birling 6 ; Pavlovic, Guillaume 6 ; Lalanne, Valérie 6 ; Lux, Aline 6 ; Riet, Fabrice 6 ; Mittelhaeuser, Christophe 6 ; Bour, Raphael 6 ; Guimond, Alain 6 ; Chaouki Bam’Hamed 6 ; Leblanc, Sophie 6 ; Vasseur, Laurent 6 ; Selloum, Mohammed 6 ; Sorg, Tania 6 ; Ayabe, Shinya 7 ; Furuse, Tamio 7 ; Kaneda, Hideki 7 ; Kobayashi, Kimio 7 ; Masuya, Hiroshi 7 ; Miura, Ikuo 7 ; Obata, Yuichi 7 ; Suzuki, Tomohiro 7 ; Tamura, Masaru 7 ; Tanaka, Nobuhiko 7 ; Yamada, Ikuko 7 ; Yoshiki, Atsushi 7 ; Berberovic, Zorana 8 ; Bubshait, Mohammed 8 ; Cabezas, Jorge 8 ; Carroll, Tracy 8 ; Clark, Greg 8 ; Clarke, Shannon 8 ; Creighton, Amie 8 ; Danisment, Ozge 8 ; Eskandarian, Mohammad 8 ; Feugas, Patricia 8 ; Gertsenstein, Marina 8 ; Guo, Ruolin 8 ; Hunter, Jane 8 ; Jacob, Elsa 8 ; Lan, Qing 8 ; Laurin, Valerie 8 ; Law, Napoleon 8 ; MacMaster, Sue 8 ; Miller, David 8 ; Morikawa, Lily 8 ; Newbigging, Susan 8 ; Owen, Celeste 8 ; Penton, Patricia 8 ; Pereira, Monica 8 ; Qu, Dawei 8 ; Shang, Xueyuan 8 ; Sleep, Gillian 8 ; Khondoker Sohel 8 ; Tondat, Sandra 8 ; Wang, Yanchun 8 ; Vukobradovic, Igor 8 ; Zhu, Yingchun 8 ; Chiani, Francesco 9 ; Chiara Di Pietro 9 ; Gianfranco Di Segni 9 ; Ermakova, Olga 9 ; Ferrara, Filomena 9 ; Fruscoloni, Paolo 9 ; Gambadoro, Aalessia 9 ; Gastaldi, Serena 9 ; Golini, Elisabetta 9 ; Gina La Sala 9 ; Mandillo, Silvia 9 ; Marazziti, Daniela 9 ; Massimi, Marzia 9 ; Matteoni, Rafaele 9 ; Orsini, Tiziana 9 ; Pasquini, Miriam 9 ; Raspa, Marcello 9 ; Rauch, Aline 9 ; Rossi, Gianfranco 9 ; Rossi, Nicoletta 9 ; Putti, Sabrina 9 ; Scavizzi, Ferdinando 9 ; Tocchini-Valentini, Giuseppe D 9 ; Beig, Joachim 10 ; Bürger, Antje 10 ; Giesert, Florian 10 ; Graw, Jochen 10 ; Kühn, Ralf 10 ; Oritz, Oskar 10 ; Schick, Joel 10 ; Seisenberger, Claudia 10 ; Amarie, Oana 11 ; Garrett, Lillian 11 ; Hölter, Sabine M 11 ; Zimprich, Annemarie 11 ; Aguilar-Pimentel, Antonio 12 ; Beckers, Johannes 12 ; Brommage, Robert 12 ; Calzada-Wack, Julia 12 ; Fuchs, Helmut 12 ; Gailus-Durner, Valérie 12 ; Lengger, Christoph 12 ; Leuchtenberger, Stefanie 12 ; Maier, Holger 12 ; Marschall, Susan 12 ; Moreth, Kristin 12 ; Neff, Frauke 12 ; Östereicher, Manuela A 12 ; Rozman, Jan 12 ; Steinkamp, Ralph 12 ; Stoeger, Claudia 12 ; Treise, Irina 12 ; Stoeger, Tobias 13 ; Ali Önder Yildrim 13 ; Eickelberg, Oliver 14 ; Becker, Lore 15 ; Klopstock, Thomas 16 ; Ollert, Markus 17 ; Busch, Dirk H 18 ; Schmidt-Weber, Carsten 19 ; Bekeredjian, Raffi 20 ; Zimmer, Andreas 21 ; Rathkolb, Birgit 22 ; Wolf, Eckhard 23 ; Klingenspor, Martin 24 ; Tocchini-Valentini, Glauco P 9 ; Gao, Xiang 25 ; Bradley, Allan 4 ; Skarnes, William C 4 ; Moore, Mark 26 ; Beaudet, Arthur L 27 ; Justice, Monica J 28 ; Seavitt, John 27 ; Dickinson, Mary E 29 ; Wurst, Wolfgang 10 ; Martin Hrabe de Angelis 12
; Herault, Yann 30
; Wakana, Shigeharu 7
; Nutter, Lauryl M J 8 ; Flenniken, Ann M 8 ; McKerlie, Colin 8
; Murray, Stephen A 31 ; Svenson, Karen L 31 ; Braun, Robert E 31 ; West, David B 32 ; Lloyd, K C Kent 5
; Adams, David J 4 ; White, Jacqui 4 ; Karp, Natasha 4 ; Flicek, Paul 3
; Smedley, Damian 33
; Meehan, Terrence F 3 ; Parkinson, Helen E 3 ; Teboul, Lydia M 1 ; Wells, Sara 1 ; Steel, Karen P 2 ; Mallon, Ann-Marie 1 ; Brown, Steve D M 1 1 Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, UK
2 King’s College London, London, UK; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
3 European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
4 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
5 Mouse Biology Program, University of California, Davis, California, USA
6 CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), Illkirch-Graffenstaden, France
7 RIKEN BioResource Center, Tsukuba, Ibaraki, Japan
8 The Centre for Phenogenomics, Toronto, Ontario, Canada; The Hospital for Sick Children, Toronto, Ontario, Canada; Canada and Mount Sinai Hospital, Toronto, Ontario, Canada
9 Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, Monterotondo Scalo, Italy
10 Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany
11 Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany
12 German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany
13 German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Center for Lung Research, Gießen, Germany
14 Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Center for Lung Research, Gießen, Germany
15 German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany; Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, Munich, Germany
16 Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, Munich, Germany
17 Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg; Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis, University of Southern Denmark, Odense, Denmark
18 Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
19 Center of Allergy & Environment (ZAUM), Technische Universität München, and Helmholtz Zentrum München, Ingolstaedter Landstrasse, Neuherberg, Germany
20 Department of Cardiology, University of Heidelberg, Heidelberg, Germany
21 Institute of Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany
22 German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany; Ludwig-Maximilians-Universität München, Gene Center, Institute of Molecular Animal Breeding and Biotechnology, Munich, Germany
23 Ludwig-Maximilians-Universität München, Gene Center, Institute of Molecular Animal Breeding and Biotechnology, Munich, Germany
24 Institute for Food and Health, Technical University Munich, Freising-Weihenstephan, Germany
25 SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China
26 IMPC, San Anselmo, California, USA
27 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
28 The Centre for Phenogenomics, Toronto, Ontario, Canada; The Hospital for Sick Children, Toronto, Ontario, Canada; Canada and Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
29 Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA
30 CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), Illkirch-Graffenstaden, France; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, Illkirch, France; Centre National de la Recherche Scientifique, UMR7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale, Illkirch, France
31 The Jackson Laboratory, Bar Harbor, Maine, USA
32 Childrens’ Hospital Oakland Research Institute, Oakland, California, USA
33 Queen Mary University of London, London, UK
Pages
1-11
Publication year
2017
Publication date
Oct 2017
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
1950401967
Copyright
© 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.