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About the Authors:
Vanessa Dumeaux
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Software, Writing - original draft, Writing - review & editing
* E-mail: [email protected]
Affiliations Department of Biology, Concordia University, Montreal, QC, Canada, School of Computer Science, McGill University, Montreal, QC, Canada
ORCID http://orcid.org/0000-0002-9904-8092
Bjørn Fjukstad
Roles Software, Writing - review & editing
Affiliation: Department of Computer Science, UiT the Arctic University of Norway, Tromsø, Norway
Hans E. Fjosne
Roles Resources
Affiliations Department of Surgery, St. Olavs University Hospital, Trondheim, Norway, Faculty of Medicine, The Norwegian University of Technology and Science, Trondheim, Norway
Jan-Ole Frantzen
Roles Resources
Affiliation: University Hospital of North-Norway, Narvik, Norway
Marit Muri Holmen
Roles Resources
Affiliation: Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway
ORCID http://orcid.org/0000-0003-2803-4117
Enno Rodegerdts
Roles Resources
Affiliation: Nordland Central Hospital, Bodø, Norway
Ellen Schlichting
Roles Resources
Affiliation: Department of Cancer, Oslo University Hospital, Oslo, Norway
Anne-Lise Børresen-Dale
Roles Resources
Affiliation: Department of Cancer Genetics, Oslo University Hospital, Oslo, Norway
Lars Ailo Bongo
Roles Software, Writing - review & editing
Affiliation: Department of Computer Science, UiT the Arctic University of Norway, Tromsø, Norway
ORCID http://orcid.org/0000-0002-7544-2482
Eiliv Lund
Contributed equally to this work with: Eiliv Lund, Michael Hallett
Roles Conceptualization, Funding acquisition, Writing - review & editing
Affiliation: Institute of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway
ORCID http://orcid.org/0000-0002-8071-8711
Michael Hallett
Contributed equally to this work with: Eiliv Lund, Michael Hallett
Roles Funding acquisition, Methodology, Writing - original draft, Writing - review & editing
Affiliations Department of Biology, Concordia University, Montreal, QC, Canada, School of Computer Science, McGill University, Montreal, QC, Canada
ORCID http://orcid.org/0000-0001-6738-6786Abstract
Although systemic immunity is critical to the process of tumor rejection, cancer research has largely focused on immune cells in the tumor microenvironment. To understand molecular changes in the patient systemic response (SR) to the presence of BC, we profiled RNA in blood and matched tumor from 173 patients. We designed a system (MIxT, Matched Interactions Across Tissues) to systematically explore and link molecular processes expressed in each tissue. MIxT confirmed that processes active in the patient SR are especially relevant to BC immunogenicity. The nature of interactions across tissues (i.e. which biological processes are associated and their patterns of expression) varies highly with tumor subtype. For example,...