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Abstract
Key messages * Coenzyme Q10 is an essential component of the mitochondrial electron transport chain. * In this placebo-controlled, randomized, pilot trial we found that enteral administration of ubiquinol (reduced coenzyme Q10) increases total Coenzyme Q10 levels, Coenzyme Q10 levels relative to cholesterol levels, and levels of oxidized and reduced Coenzyme Q10. * There was no difference in vascular endothelial biomarkers, inflammatory biomarkers, or biomarkers related to mitochondrial injury, including cytochrome c levels. * We found no difference in clinical outcomes between the ubiquinol and placebo groups. Tumor necrosis factor VCAM-1: Vascular cell adhesion molecule VEGF: The authors wish to acknowledge and thank the members of the Data Safety Monitoring Board, Dr. Peter Clardy, Beth Israel Deaconess Medical Center and Dr. David Leaf, Brigham and Women’s Hospital. R1095-102. doi:10.1152/ajpregu.90902.2008.Google Scholar American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis.