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Abstract
Key messages * This retrospective study demonstrated that 56.4 % of selected patients with ARDS based on Berlin definition, and who underwent open lung biopsy were found to have DAD. * Patients with DAD identified on pathological examination had significantly higher hospital mortality than patients without DAD, and there was no clinical characteristic that differentiated between patients with and without DAD before open lung biopsy. * In future studies, the clinical therapeutic trial may focus on patients with ARDS and DAD and investigate some non-invasive modalities to identify this subgroup of patients with ARDS. Intensive Care Med. 1999;25:930-5.Google Scholar Villar J, Kacmarek RM, Pérez-Méndez L, Aguirre-Jaime A. A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial. Chronology of histological lesions in acute respiratory distress syndrome with diff use alveolar damage: a prospective cohort study of clinical autopsies.