Content area
Abstract
Optical density PaCO2 : Partial arterial carbon dioxide tension PaO2 : Partial arterial oxygen tension TNF-?: tumor necrosis factor-? Declarations Acknowledgements The authors thank Francien van de Pol and Ilona van den Brink (lab technicians, Department of Anesthesiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands) for their expertise in performing the animal experiments. Inhaled levosimendan reduces mortality and release of proinflammatory mediators in a rat model of experimental ventilator-induced lung injury. Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling. Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite: a potential additional mechanism of nitric oxide-dependent toxicity.