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Abstract
Key messages * hCAP18 levels on ICU day 1 correlate positively with total, but not bioavailable or free 25-hydroxyvitamin D levels. * Lower hCAP18 levels on ICU day 1 are associated with increased risk of 90-day mortality. * Vitamin D metabolites may have important effects on innate immunity via induction of hCAP18. D-binding protein eGRF: estimated glomerular filtration rate ELISA: enzyme-linked immunosorbent assay hCAP18: human cathelicidin antimicrobial protein-18 ICU: intensive care unit IQR: interquartile range PTH: parathyroid hormone RCT: randomized controlled trial Rs : Spearman’s rho Declarations Acknowledgements D.E.L. is supported by 1F32DK100040 from the National Institute of Diabetes and Digestive and Kidney Diseases. Worsening severity of vitamin D deficiency is associated with increased length of stay, surgical intensive care unit cost, and mortality rate in surgical intensive care unit patients. Effect of high-dose vitamin D3 on hospital length of stay in critically Ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial.