Content area
Abstract
Introduction Micafungin (MCF) is an echinocandin agent with broad activity against Candida spp., which are frequently isolated in blood and eschar cultures of burned patients, who present different pharmacokinetics (PK) characteristics. Peak plasma concentrations after the first and repeated doses of MCF were inversely correlated with % burned TBSA (Spearman's ? = -0.695 and -0.750 (P < 0.05)), respectively, but not with the time from burn injury. Patient % burned TBSA % FT ABSI MCF dose (mg/kg body weight) Plasma Cmax/Cmin after first dose (?g/ml) Plasma C/max/Cmin at steady state (?g/ml) Burn easchar tissue on day 5 (?g/ml) Days from admission to the start of MCF SOFA at the beginning of MCF LOS in BUCU (days) 1 35 20 9 1.3 8.6/0.8 7.4/1.0 2.3 38 1 75 2 40 35 8 2.0 8.5/1.1 9.4/1.8 <LQ 15 6 23 3 23 16 8 1.3 6.4/0.8 10.3/1.2 <LQ 12 2 17 4 70 40 12 1.1 3.9/0.5 4.5/0.8 0.4 8 6 43 5 23 12 7 1.3 7.5/1.8 8.0/1.4 0.6 10 5 19 6 70 60 11 1.2 3.4/0.5 5.0/0.9 1.5 12 5 70 7 80 70 12 1.1 3.8/0.4 4.0/0.4 0.2 34 2 61 8 60 50 10 1.4 4.8/0.5 4.3/1.0 0.2 34 2 90 9 44 34 10 1.3 4.5/1.1 9.1/2.3 0.2 8 6 34 10 34 28 9 1.3 4.1/0.7 5.4/1.0 0.7 10 5 35 Median 42 34.5 9.5 1.3 4.7/0.7 6.4/1.0 0.5 12 5.0 39 IQR 31.3 to 70.0 19.0 to 52.5 8 to 11.3 1.1 to 1.4 3.9 to 7.5/0.5 to 1.1 4.5 to 9.1/0.9 to 1.4 0.3 to 1.1 9.5 to 19.8 3.5 to 5.6 22.7 to 71.3 ABSI, Abbreviated Burn Severity Index; BICU, burn intensive care unit; FT, full thickness; IQR, interquartile range; LOS, length of hospital stay; LQ, limit of quantification (<0.1 ?g/ml); SOFA, Sequential Organ Failure Assessment; TBSA, total body surface area.