Abstract

Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.

Details

Title
Hydantoins: Synthesis, properties and anticonvulsant activity
Author
Trišović, Nemanja P  VIAFID ORCID Logo  ; Ušćumlić, Gordana S
Pages
17-31
Publication year
2009
Publication date
2009
Publisher
Hemijska Industrija
ISSN
0367598X
e-ISSN
22177426
Source type
Scholarly Journal
Language of publication
Serbian; English
DOI
https://doi.org/10.2298/HEMIND0901017T
ProQuest document ID
1956175077
Copyright
© 2009. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.