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Abstract
In vitiligo, chronic loss of melanocytes and consequent absence of melanin from the epidermis presents a challenge for long-term tissue maintenance. The stable vitiligo patches are known to attain an irreversible depigmented state. However, the molecular and cellular processes resulting in this remodeled tissue homeostasis is unclear. To investigate the complex interplay of inductive signals and cell intrinsic factors that support the new acquired state, we compared the matched lesional and non-lesional epidermis obtained from stable non-segmental vitiligo subjects. Hierarchical clustering of genome-wide expression of transcripts surprisingly segregated lesional and non-lesional samples in two distinct clades, despite the apparent heterogeneity in the lesions of different vitiligo subjects. Pathway enrichment showed the expected downregulation of melanogenic pathway and a significant downregulation of cornification and keratinocyte differentiation processes. These perturbations could indeed be recapitulated in the lesional epidermal tissue, including blunting of rete-ridges, thickening of stratum corneum and increase in the size of corneocytes. In addition, we identify marked increase in the putrescine levels due to the elevated expression of spermine/spermidine acetyl transferase. Our study provides insights into the intrinsic self-renewing ability of damaged lesional tissue to restore epidermal functionality in vitiligo.
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Details
1 CSIR-Institute of Genomics and Integrative Biology, New Delhi, India
2 CSIR-Institute of Genomics and Integrative Biology, New Delhi, India; Academy of Scientific and Innovative Research, New Delhi, India
3 Turku Centre for Biotechnology, University of Turku and ÅboAkademi University, Turku, Finland
4 CSIR-National Chemical Laboratory, Chemical Engineering Division, Pune, India
5 National Institute of Immunology, New Delhi, India
6 Department of Dermatology, Post Graduate Institute for Medical Education and Research (PGIMER), Dr. Ram Manohar Lohia Hospital, New Delhi, India
7 Department of Dermatology, Dr. D. Y. Patil Medical College, Pune, India
8 MelanoSite, Center for Advanced Vitiligo Treatment and Collaborative Pigment Cell Research, New Delhi, India
9 School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
10 CSIR-Institute of Genomics and Integrative Biology, New Delhi, India; National Institute of Immunology, New Delhi, India; CSIR-National Chemical Laboratory, Chemical Engineering Division, Pune, India; Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru, India