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Abstract
Significant difference was analyzed with ANOVA Tukey’s test, *p < 0.05 and **p < 0.01 HMW bathing decreases serum IgE level in hairless mice with DNCB-induced AD-like inflammation AD in hairless mice is known to be frequently mediated by IgE. [...]to further investigate whether bathing in PHMW and DHMW on DNCB-induced hairless mice, retro-orbital bleeding samples were taken on the last day of the 4th week of treatment. Significant difference was analyzed with ANOVA Tukey’s test, *p < 0.05 HMW bathing effects on inflammatory cytokines in hairless mice with DNCB-induced AD-like inflammation Imbalance of cytokines network has been found in AD. [...]we examined the effect of PHMW and DHMW bathing on serum cytokine profiles in DNCB-induced hairless mice. [...]to explore the linkage of redox imbalance in the pathophysiology of AD, we analyzed different oxidative stress markers. [...]allergic reactions in the skin with allergens is known to affect the antioxidant defense system such as antioxidant enzymes. [...]to examine the bathing effect of HMW on the antioxidant defense system of the DNCB-induced mice, we measured GPx activity in both treatment and control groups and found that there was the significance enhanced activity of GPx in PHMW group compared to the NeC and PC groups (Fig. 6c).