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Abstract

With the highly dense genomic data available nowadays, ignoring linkage between genes would result in a huge loss of information. One way to prevent such a loss is to focus on the blocks of chromosomes shared identical by descent (IBD) in populations. The development of the theoretical framework modelling IBD processes is essential to support the advent of new tools such as haplotype phasing, imputation, inferring population structure and demographic history, mapping loci or detecting signatures of selection. This article aims to present the relevant models used in this context, and specify the underlying definitions of identity by descent that are yet to be gathered at one place. In light of this, we derived a general expression for the expected IBD block length, for any population model at any generation after founding.

Details

1009240
Title
Blocks of chromosomes identical by descent in a population: Models and predictions
Publication title
PLoS One; San Francisco
Volume
12
Issue
11
First page
e0187416
Publication year
2017
Publication date
Nov 2017
Section
Research Article
Publisher
Public Library of Science
Place of publication
San Francisco
Country of publication
United States
e-ISSN
19326203
Source type
Scholarly Journal
Language of publication
English
Document type
Journal Article
ProQuest document ID
1959228684
Document URL
https://www.proquest.com/scholarly-journals/blocks-chromosomes-identical-descent-population/docview/1959228684/se-2?accountid=208611
Copyright
© 2017 Tiret, Hospital. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Last updated
2024-10-02
Database
2 databases
  • ProQuest One Academic
  • ProQuest One Academic