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Declarations

Authors’ contributions

Study design: CG, BM, DD, AB. Experiments: DD, AB. Tissue Acquisition and pathological evaluation: AB. Morphometric analysis: DD, GT. Analysis of published data sets: ZNE, TM, DD. Writing of the manuscript: CG, BM, DD, AB. Reviewing of the manuscript: All authors read and approved the final manuscript.

Acknowledgements

The authors gratefully acknowledge expert technical assistance by Xenia Hudec.

Competing interests

The authors declare that they have no competing interests.

Availability of data and materials

Protein data was submitted to the ProteomeXchange Consortium via the PRIDE partner repository and can be accessed via http://www.proteomeexchange.org with the identifier PXD00.

Consent for publication

All authors have seen the manuscript and agree to its publication.

Ethics approval and consent to participate

The study was approved by the Ethics Commission of the Medical University of Vienna (EK 1659/2012). Patients suffering from colorectal cancer who underwent surgery at the General Hospital of Vienna were asked for their informed consent to use part of the resected tissue for analysis of tumor protein markers.

Funding

This project was supported by grants from the Austrian National Bank (15655) and the Austrian Science Fund (P26218).

Publisher’s Note

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Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Additional files

12014_2017_9168_MOESM1_ESM.docx Additional file 1: Figures S1: Epithelia/Stromal separation. Figure S2. mRNA levels for proteins increased in the tumor. Figure S3. mRNA levels of proteins decreased in the tumor. Figure S4. Quantification of THBS2 staining in IHC slides from the original 6 patients.

12014_2017_9168_MOESM2_ESM.xlsx Additional file 2. Table S1. Proteins identified in colorectal tumors and normal mucosa.

12014_2017_9168_MOESM3_ESM.xlsx Additional file 3. Table S2. Significantly altered proteins in colorectal tumors.

12014_2017_9168_MOESM4_ESM.xlsx Additional file 4. Table S3. GO-term enrichment analysis based on biological process.

References

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