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Abstract
Objective: This study aims to determine and verify the use of ethanol extract of Erythrina variegata leaves ethanol extract as a stimulant of hair growth or anti-alopecia.
Methods: The E.variegate leaves were collected from Salawu tribe, Tasikmalaya, West Java. The extraction was done by maceration which was based on the standard method of Indonesian Herbal Pharmacopeia. The viscous concentrated extract was fractionated by liquid-liquid extraction. Phytochemical screening according to the Farnsworth method. Method of hair growth on Angora type rabbit was modified of Tanaka method.
Results: The results of phytochemical screening using Farnsworth method showed the ethanol extract containing secondary metabolite of tannin compound, polyphenol, steroid, triterpenoid, quinone, monoterpenoid and sesquiterpenoid. The results of hair fertilizer testing using Tanaka method showed that ethanol extract and water extract with 20%, 15%, 10% concentration significantly could fertilize hair with a test for 18 days. Extracts of ethanol with levels greater than 10% showed better results. Water fraction of 10% appeared to show the best result for rabbit hair growth overcome minoxidil.
Conclusions: This work found that the concentration of 10% ethanol extract of Erythrina variegata and its water fractions were effective for hair growth on male rabbits. It was suggested, however, for further study to determine the compound which was responsible by using elucidation methods.
Keywords: Hair fertilization, ethanol extract, Erythrina variegata, hair grower, Alopecia, phytochemical screening
INTRODUCTION
Baldness is normally known as the phenomenon of aging but is associated with many other factors [1] namely, endocrine abnormalities, genetic predisposition, systemic disease, drugs, physiological abnormalities, infections, autoimmune and hair structure damage [2]. The use of hair cosmetics such as hair coloring, hair straightening, and hair curlers that too often can affect the health, strength, and fertility of hair so that one cause of hair loss over time can be severe even baldness. As many as 95% of users of hair straightener in the United States and 53% of users in Africa reported damage or hair loss due to hair straightener [3]. In addition, the habit of binding and braiding hair can also cause baldness or alopecia [4]. One of the late chemical drugs proven effective as baldness therapy is the minoxidil solution. However, minoxidil has a side effect of exfoliation during the first 4 months...