Abstract

Reference region selection is important for proper amyloid PET analysis, especially in subcortical vascular dementia (SVaD) patients. We investigated reference region differences between SVaD and Alzheimer’s disease (AD) using Centiloid scores. In 57 [C-11] Pittsburgh compound B (PiB) positive (+) AD and 23 PiB (+) SVaD patients, we assessed standardized PiB uptake and Centiloid scores in disease-specific cortical regions, with several reference regions: cerebellar gray (CG), whole cerebellum (WC), WC with brainstem (WC + B), pons, and white matter (WM). We calculated disease group differences from young controls (YC) and YC variance according to reference region. SVaD patients showed large effect sizes (Cohen’s d > 0.8) using all reference regions. WM and pons showed larger YC variances than other regions. Findings were similar for AD patients. CG, WC, and WC + B, but not WM or pons, are reliable reference regions for amyloid imaging analysis in SVaD.

Details

Title
Centiloid method evaluation for amyloid PET of subcortical vascular dementia
Author
Hyuk Jin Yun 1 ; Moon, Seung Hwan 2 ; Hee Jin Kim 3 ; Lockhart, Samuel N 4   VIAFID ORCID Logo  ; Choe, Yearn Seong 2 ; Kyung Han Lee 2 ; Na, Duk L 5 ; Jong-Min, Lee 6 ; Seo, Sang Won 7 

1  Department of Biomedical Engineering, Hanyang University, Seoul, Korea; Fetal Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA 
2  Department of Nuclear Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea 
3  Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Neuroscience Center, Samsung Medical Center, Seoul, Korea 
4  Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA; Department of Internal Medicine, Division of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA 
5  Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Neuroscience Center, Samsung Medical Center, Seoul, Korea; Department of Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea 
6  Department of Biomedical Engineering, Hanyang University, Seoul, Korea 
7  Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Neuroscience Center, Samsung Medical Center, Seoul, Korea; Department of Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea; Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea 
Pages
1-8
Publication year
2017
Publication date
Nov 2017
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-017-16236-1
ProQuest document ID
1968049456
Copyright
© 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.