Abstract

Antidiabetic medication may modulate the gut microbiota and thereby alter plasma and faecal bile acid (BA) composition, which may improve metabolic health. Here we show that treatment with Acarbose, but not Glipizide, increases the ratio between primary BAs and secondary BAs and plasma levels of unconjugated BAs in treatment-naive type 2 diabetes (T2D) patients, which may beneficially affect metabolism. Acarbose increases the relative abundances of Lactobacillus and Bifidobacterium in the gut microbiota and depletes Bacteroides, thereby changing the relative abundance of microbial genes involved in BA metabolism. Treatment outcomes of Acarbose are dependent on gut microbiota compositions prior to treatment. Compared to patients with a gut microbiota dominated by Prevotella, those with a high abundance of Bacteroides exhibit more changes in plasma BAs and greater improvement in metabolic parameters after Acarbose treatment. Our work highlights the potential for stratification of T2D patients based on their gut microbiota prior to treatment.

Details

Title
Analyses of gut microbiota and plasma bile acids enable stratification of patients for antidiabetic treatment
Author
Gu, Yanyun 1   VIAFID ORCID Logo  ; Wang, Xiaokai 2 ; Li, Junhua 3   VIAFID ORCID Logo  ; Zhang, Yifei 1 ; Zhong, Huanzi 4   VIAFID ORCID Logo  ; Liu, Ruixin 1 ; Zhang, Dongya 5 ; Feng, Qiang 5 ; Xie, Xiaoyan 1 ; Hong, Jie 1 ; Ren, Huahui 6 ; Liu, Wei 7 ; Ma, Jing 7 ; Su, Qing 8 ; Zhang, Hongmei 8 ; Yang, Jialin 9 ; Wang, Xiaoling 10 ; Zhao, Xinjie 10 ; Gu, Weiqiong 1 ; Bi, Yufang 1 ; Peng, Yongde 11 ; Xu, Xiaoqiang 2 ; Xia, Huihua 3 ; Li, Fang 6 ; Xu, Xun 5 ; Yang, Huanming 12 ; Xu, Guowang 10   VIAFID ORCID Logo  ; Madsen, Lise 13   VIAFID ORCID Logo  ; Kristiansen, Karsten 4   VIAFID ORCID Logo  ; Ning, Guang 1 ; Wang, Weiqing 1 

1  Shanghai National Research Centre for Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 
2  BGI-Shenzhen, China National GeneBank-Shenzhen, Shenzhen, China; BGI Education Centre, University of Chinese Academy of Sciences, Shenzhen, China 
3  BGI-Shenzhen, China National GeneBank-Shenzhen, Shenzhen, China; Shenzhen Key Laboratory of Human commensal microorganisms and Health Research, BGI-Shenzhen, Shenzhen, China 
4  BGI-Shenzhen, China National GeneBank-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark 
5  BGI-Shenzhen, China National GeneBank-Shenzhen, Shenzhen, China 
6  BGI-Shenzhen, China National GeneBank-Shenzhen, Shenzhen, China; Shenzhen Key Laboratory of Human commensal microorganisms and Health Research, BGI-Shenzhen, Shenzhen, China; Shenzhen Engineering Laboratory of Detection and Intervention of human intestinal microbiome, BGI-Shenzhen, Shenzhen, China 
7  Renji Hospital affiliated to Shanghai Jiaotong University Medical School, Shanghai, China 
8  Xinhua Hospital affiliated to Shanghai Jiaotong University Medical School, Shanghai, China 
9  MinHang Central Hospital affiliated to Fudan University Medical School, Shanghai, China 
10  Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian, China 
11  Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China 
12  BGI-Shenzhen, China National GeneBank-Shenzhen, Shenzhen, China; James D. Watson Institute of Genome Sciences, Hangzhou, China 
13  BGI-Shenzhen, China National GeneBank-Shenzhen, Shenzhen, China; BGI Education Centre, University of Chinese Academy of Sciences, Shenzhen, China; National Institute of Nutrition and Seafood Research (NIFES), Bergen, Norway 
Pages
1-12
Publication year
2017
Publication date
Nov 2017
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-017-01682-2
ProQuest document ID
1968412227
Copyright
© 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.