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Headnote
S9
A vulnerable mood during the premenstrual phase has been highly related to Iuteal function. A complex interaction between estrogen and progesterone is operating within the ClNS and a peculiar sensi tivity to progesterone metabolites seems to be present in women with PMS and PMl)I). The pattern of mood changes during sequential HRT shows some similarities with premenstrual cyclic mood swings and is modulated by estrogen dose and type of progestogens. Even though data from the liter ature at regard are mixed, it is reasonably to affirm that progestogen -related negative side -effects affect the...