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ABSTRACT:
Quinazoline, a heterocyclic compound, has been extensively studied and used in certain specific biological activities. The quinazoline-4(3H)-one and its derivatives constitute an important class of fused heterocycles that are found in more than 200 naturally occurring alkaloids. With a passage of time, newer and more complex variants of the quinazolinone structures are being discovered. The stability of the quinazolinone nucleus has inspired researchers to introduce many bioactive moieties to this nucleus to create new potential medicinal agents. They exhibit broad spectrum of biological activities such as anti-HIV, anticancer, antifungal, antibacterial, antimutagenic, anticonvulsant, anti-inflammatory, antidepressant, antimalarial, antioxidant, antileukemic, and antileishmanial activities and other activities. Here in this research, we are dealing with the antimicrobial activity of various 3phenyls substituted quinazolin 4-(3H)- one.
KEYWORDS: Quinazolin 4-(3H)- one, hetero cyclic anilines, Anti fungal, Antibacterial.
INTRODUCTION:
Quinazoline is a compound made up of two fused sixmembered aromatic rings a benzene ring and pyrimidine ring. Its chemical formula is CgftC Quinazoline is yellow colour and found in the crystalline form. Quinazoline is a fused bicyclic compound earlier known as benzo-1,3diazine was first prepared in the laboratory by Gabriell in 1903, although one of its derivatives was earlier known much earlier.
The name quinazoline was proposed for this compound by Weddige, on observing that this was isomeric with the compounds cinnoline and quinoxaline. Paal and Bush suggested the numbering of quinazoline system, which is currently used. The other less commonly used names for this ring system are 'phenmiazine' and 5,6benzopyrimi dine.
Depending upon the position of keto or oxo group, this compound may be classified into two types: 1,2-(1H) quinazolinone (or) 1,2- dihydro-2-oxo quinazolines,2,4(3H)-quinazoline or 3,4 dihydro-oxo quinazolines. These two system exhibits lactam-lactam tautomerism and undergo hydroxy group replacement reactions.
CHEMISTRY OF QUINAZOLINONE:
Common name: Quinazolinone and Quinazolindion. Chemical name is found to be Quinazolin-4(3H)-one (Chen et al., 2006), 4(3H)- Quinazolinone, 3,4Dihydroquinazolin-4-one, (3H)-Quinazolone, 4-Oxo3,4-dihydroquinazoline, 4-oxoquinazolinol, 4Quinazolinone. Chemicals with two conjoined aromatic rings incorporating two nitrogen atoms and one of the carbons oxidized with keto oxygen. Quinazolinone is a heterocyclic chemical compound. There are two structural isomers, 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. Quinazolinones are also a class of drugs which function as hypnotic/sedatives that contain a 4-quinazolinone core. Their use has also been proposed in...