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Abstract
One of the diabetes complication is delayed wound healing in oral traumatic ulcer. Tinospora crispa contains flavonoid and terpenoid which can help to control blood glucose level and accelerate wound healing.
The aim of this study is to analyze brotowali (Tinospora crispa) extract potential in controlling blood glucose level and accelerating ulcer healing process. The extract was made with oven-dried method at 50°C and macerated with ethanol 80% (1:10 w/v). The rats were divided into 3 groups, control group I (K1) normal Wistar Rat with traumatic ulcer, control group II (K2) diabetes mellitus wistar rat with traumatic ulcer, and treatment group (P) diabetes mellitus wistar rat with traumatic ulcer treated with 250 mg/kg tinospora crispa extract once a day. Sample were euthanized on 3rd, 5th, and, 7th day after traumatic ulcer was made then a histopathology preparation was made to count fibroblast cell. Blood glucose level measurement was conducted on 3rd, 5th, 7th, and 14th after traumatic ulcer was made.
Brotowali extract can affect blood glucose levels but make no significant difference and affect the number of fibroblasts in traumatic ulcers healing diabetes mellitus Wistar rats with significant difference.
Experimental article (J Int Dent Med Res 2017; 10(3): pp. 991-996)
Keywords: Traumatic ulcer, Wound healing, Tinosporacrispa, Diabetes mellitus, Fibroblast cell.
Received date: 31 August 2017_Accept date: 13 October 2017
Introduction
Diabetes mellitus defined as a multi factorial disease or chronic metabolism disorder, characterized by elevated blood glucose level, carbohydrate, lipids and protein metabolism disturbance in consequence of insulin insufficiency. Insulin insufficiency may be caused by disturbance or insufficient insulin production by beta Langerhans cells of pancreas1.
Indonesia is the fourth country that has the highest diabetes mellitus prevalence2. According to report from Basic Health Research (Riskesdas) 2013, the prevalence of diabetes mellitus in Indonesia is 6,9% or equivalent to 12,1 million patients3. According to research by Diabcare, type 2 uncontrolled diabetes mellitus patient reached 47,2% with plasma glucose level >130mg/dL4.
Diabetes Mellitus have various complications related to dentistry, one of them is traumatic ulcer5,6. Traumatic ulcer is single mucosa ulcer that can be caused by mechanic, thermal, chemical, or direct physical trauma to the mucosa7,8. Traumatic ulcers were more common in diabetes mellitus patient than in normal person. This may be caused by...