Content area
Full text
Introduction
Myocardial infarction (MI), commonly referred to as a heart attack, occurs when blood flow stops to part of the heart causing damage to the heart muscle (1). With increasing morbidity and death rates, it has become a great threat to human health. The leading cause of MI at the acute phase is acute heart failure (2). With the development of medical techniques, thrombolysis, interventional stent and bypass surgery have greatly decreased mortality rates of the conversion from acute MI to acute heart failure (3). However, heart failure can be become chronic. Priority is given to remodeling of cardiac fibrosis for chronic MI. Excessive cardiac fibrosis remodeling causes heart failure.
As an inhalation anesthetic, isoflurane is does not irritate the respiratory system (4). When used as an anesthesia for teenagers, adults and the elderly, it is stable in induction with high recovery quality (5). N2O is not toxic, has strong analgesic effects and patients are quickly awoken (5). Consequently, it is widely employed in clinics.
With high lipid solubility and low water solubility, blood concentrations of N2O peak after intravenous injection of 2.5 mg/kg of propofol after 2 min (6). Redistribution quickly occurs, resulting in a quick decrease in blood concentration (5). Characterized by quickly taking effect without drug accumulation and patients being easily awoken, propofol metabolizes in the liver and its elimination half life is 30–60 min (7). Fentanyl is a newly discovered narcotic opiate analgesic, which has similar pharmacological functions to other opiates, such as relieving pain and calming (8). The efficacy of fentanyl peaks 3–5 min after intravenous injection and metabolizes through the liver. Its terminal half time is 2 to 4 h (9). With specific pharmacokinetic features, it takes effect fast and peaks after 1.6 min of intravenous injection. It can be degraded via non-specific esterase in red blood cells and tissues (10). With a terminal half life of 0.1 to 0.6 h, its clearance rates are not influenced by hepatic and renal functions, which is a key advantage in addition to its high safety index, short waking time, reduced respiratory depression and stable hemodynamics (11).
In the present study, the effect of isoflurane + N2O inhalation and propofol + fentanyl anesthesia on myocardial function...