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Sir,
Symmetrical interdigital hyperkeratosis is a rare disorder described by Frei in 1923 [1]. He reported a case of a patient with congenital circumscribed hyperkeratosis of the interdigital spaces of the hands and feet. There was a slight hyperkeratosis on the dorsal aspects of some interphalangeal joints and on the elbows and knees. No keratoderma or hyperhydrosis of the palms and soles was observed. Frei named this condition “Congenital Symmetrical Interdigital Hyperkeratosis”.
A 35-year-old man presented with a symmetrical keratoderma localized to the interdigital spaces of the fingers. Skin thickening was developed when he was 15 years old. There was no relevant family history. There were no occupational and traumatic factors those could have affected this condition. There were no symptoms or signs of preceding infections. On physical examination, there were dark brownish colored hyperkeratotic plaques on his both first, second, third interdigital spaces of hands and the lesions slightly extended over dorsal aspects of some metacarpophalangeal joints of hands (Fig. 1 [See PDF]). At the palm, there were no keratoderma and hyperhidrosis. The finger nails were normal. Skin biopsy showed orthokeratotic hyperkeratosis, hypergranulosis, acanthosis (Fig. 2 [See PDF]). Although he was treated with keratolytics, there was no...