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SOURCE: Mina MJ, Metcalf JE, de Swart RL, et al. Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality. Science 2015;348:694-699.
The effect of measles vaccination was studied using population-level data before and after the introduction of measles vaccination approximately 50 years ago in England and Wales, the United States, and Denmark. There was a strong association of measles vaccination in these countries with declines in mortality from other childhood infectious diseases; for example, the association (after transformation of the pre-vaccine data) for the United States was R2 = 0.87. The nonspecific impact of measles vaccination was generalized and prolonged, with a duration of two to three years, with robust results across all ages studied from 1-14 years of age....