Content area
Abstract
Objective
The study was designed to examine changes of body fat distribution after laparoscopic sleeve gastrectomy (LSG) in obese male patients and to confirm whether these changes are correlated with increased testosterone.
Methods
A total of 30 obese male patients with body mass index (BMI) 30–45 kg/m2 were enrolled in this study. Data on demographic characteristics, anthropometry, metabolic parameters, and body fat distribution were collected at baseline and 6 months after LSG. Body fat distribution was assessed by dual-energy X-ray absorptiometry (DXA).
Results
Six months after surgery, the BMI of participants (age 33.0 ± 9.5) decreased from 40.2 ± 5.2 to 30.8 ± 4.4 kg/m2, total testosterone increased from 2.4 ± 1.2 to 4.5 ± 1.8 ng/mL, and the percentage of testosterone deficiency in these patients decreased from 82.7 to 23.1%. Fat mass was significantly decreased in all regions, but the loss of fat mass in the android region was more than that in any other body region. After adjusting age and the BMI, the changes in android FM% and gynoid FM% were significantly correlated with an increase in total testosterone concentration (R2 = 0.187, R2 = 0.282, respectively).
Conclusion
In obese male patients with BMI 30–45 kg/m2, an increase of total testosterone correlated to the changes in android FM% and gynoid FM% at the sixth month after LSG surgery.
Details
1 Department of Endocrinology & Metabolism, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Nanjing Medical University, Nanjing, Jiangsu Province, China
2 Department of Endocrinology & Metabolism, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
3 Department of Central Laboratory, Shanghai Tenth People’s Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
4 National Metabolic Management Center, Shanghai Tenth People’s Hospital, Shanghai, China
5 Department of Endocrinology & Metabolism, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; Nanjing Medical University, Nanjing, Jiangsu Province, China; National Metabolic Management Center, Shanghai Tenth People’s Hospital, Shanghai, China