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About the Authors:
Milène Nitenberg
Contributed equally to this work with: Milène Nitenberg, Anaïs Bénarouche
Roles Data curation, Formal analysis, Investigation, Methodology, Writing - original draft
Affiliation: Univ. Lyon, Université Lyon 1, CNRS, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, ICBMS-UMR 5246, GEMBAS team, Lyon, France
Anaïs Bénarouche
Contributed equally to this work with: Milène Nitenberg, Anaïs Bénarouche
Roles Data curation, Formal analysis, Investigation, Methodology
Affiliation: Aix-Marseille Univ, CNRS, EIPL, Marseille, France
Ofelia Maniti
Roles Conceptualization, Formal analysis, Methodology, Validation, Writing - review & editing
Affiliation: Univ. Lyon, Université Lyon 1, CNRS, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, ICBMS-UMR 5246, GEMBAS team, Lyon, France
Estelle Marion
Roles Methodology, Resources
Affiliation: CRCINA, INSERM, Université de Nantes, Université d'Angers, Angers, France
Laurent Marsollier
Roles Resources
Affiliation: CRCINA, INSERM, Université de Nantes, Université d'Angers, Angers, France
Julie Géan
Roles Conceptualization, Writing - review & editing
Affiliation: Univ. Bordeaux, CNRS, Bordeaux INP, Chemistry and Biology of Membranes and Nano-objects, CBMN UMR 5248, Pessac, France
ORCID http://orcid.org/0000-0002-6342-5562
Erick J. Dufourc
Roles Conceptualization, Funding acquisition
Affiliation: Univ. Bordeaux, CNRS, Bordeaux INP, Chemistry and Biology of Membranes and Nano-objects, CBMN UMR 5248, Pessac, France
Jean-François Cavalier
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing - review & editing
Affiliations Aix-Marseille Univ, CNRS, EIPL, Marseille, France, Aix-Marseille Univ, CNRS, LISM, Marseille, France
ORCID http://orcid.org/0000-0003-0864-8314
Stéphane Canaan
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing - review & editing
* E-mail: [email protected] (APGE); [email protected] (SC)
Affiliations Aix-Marseille Univ, CNRS, EIPL, Marseille, France, Aix-Marseille Univ, CNRS, LISM, Marseille, France
Agnès P. Girard-Egrot
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing - original draft, Writing - review & editing
* E-mail: [email protected] (APGE); [email protected] (SC)
Affiliation: Univ. Lyon, Université Lyon 1, CNRS, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, ICBMS-UMR 5246, GEMBAS team, Lyon, France
ORCID http://orcid.org/0000-0003-2612-3124Abstract
Mycolactone is a lipid-like endotoxin synthesized by an environmental human pathogen, Mycobacterium ulcerans, the causal agent of Buruli ulcer disease. Mycolactone has pleiotropic effects on fundamental cellular processes (cell adhesion, cell death and inflammation). Various cellular targets of mycolactone have been identified and a literature survey revealed that most of these targets are membrane receptors residing in ordered plasma membrane nanodomains, within which their functionalities can be modulated....