Details
Title
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors
Author
George, Julie 1 ; Vonn Walter 2 ; Peifer, Martin 3
; Alexandrov, Ludmil B 4
; Seidel, Danila 1 ; Leenders, Frauke 1 ; Maas, Lukas 1 ; Müller, Christian 1 ; Dahmen, Ilona 1 ; Delhomme, Tiffany M 5 ; Ardin, Maude 6 ; Leblay, Noemie 5 ; Byrnes, Graham 7 ; Sun, Ruping 8
; De Reynies, Aurélien 9 ; McLeer-Florin, Anne 10 ; Bosco, Graziella 1 ; Malchers, Florian 1 ; Menon, Roopika 11 ; Altmüller, Janine 12 ; Becker, Christian 13 ; Nürnberg, Peter 14 ; Achter, Viktor 15 ; Lang, Ulrich 16 ; Schneider, Peter M 17
; Bogus, Magdalena 17 ; Soloway, Matthew G 18 ; Wilkerson, Matthew D 19 ; Cun, Yupeng 3
; McKay, James D 5 ; Moro-Sibilot, Denis 20 ; Brambilla, Christian G 20 ; Lantuejoul, Sylvie 21 ; Lemaitre, Nicolas 22 ; Soltermann, Alex 23 ; Weder, Walter 24 ; Tischler, Verena 23 ; Brustugun, Odd Terje 25 ; Lund-Iversen, Marius 26 ; Helland, Åslaug 27 ; Solberg, Steinar 28 ; Ansén, Sascha 29 ; Wright, Gavin 30
; Solomon, Benjamin 31 ; Luca Roz 32 ; Pastorino, Ugo 33 ; Petersen, Iver 34 ; Clement, Joachim H 35 ; Sänger, Jörg 36 ; Wolf, Jürgen 29 ; Vingron, Martin 8
; Zander, Thomas 37 ; Perner, Sven 38 ; Travis, William D 39 ; Haas, Stefan A 8 ; Olivier, Magali 6 ; Foll, Matthieu 5 ; Büttner, Reinhard 40 ; Hayes, David Neil 18 ; Brambilla, Elisabeth 22 ; Fernandez-Cuesta, Lynnette 41 ; Thomas, Roman K 42
1 Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, Cologne, Germany
2 UNC Lineberger Comprehensive Cancer Center School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Biochemistry and Molecular Biology, Penn State Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, USA
3 Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
4 Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego, CA, USA
5 Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO), Lyon, France
6 Molecular Mechanisms and Biomarkers Group, Section of Mechanisms of Carcinogenesis, International Agency for Research on Cancer (IARC-WHO), Lyon, France
7 Section of Environment and Radiation, International Agency for Research on Cancer (IARC-WHO), Lyon, France
8 Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, Berlin, Germany
9 Programme Cartes d’Identité des Tumeurs (CIT), Ligue Nationale Contre le Cancer, Paris, France
10 CHU Grenoble Alpes, UGA/INSERM U1209/CNRS, Grenoble, France
11 NEO New Oncology GmbH, Cologne, Germany
12 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany; Institute of Human Genetics, University Hospital Cologne, Cologne, Germany
13 Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany
14 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
15 Computing Center, University of Cologne, Cologne, Germany
16 Computing Center, University of Cologne, Cologne, Germany; Department of Informatics, University of Cologne, Cologne, Germany
17 Institute of Legal Medicine, University Hospital Cologne, Cologne, Germany
18 UNC Lineberger Comprehensive Cancer Center School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
19 Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, NC, USA
20 CHUGA Grenoble, INSERM U 1209, University Grenoble Alpes, Institute of Advanced Biosciences (IAB), 38043, Grenoble, France
21 Department of Pathology, CHUGA, INSERM U 1209, University of Grenobles Alpes, Institute of Advanced Biosciences (IAB), 38043, Grenoble, France; Department of Biopathology, Centre Léon Bérard UNICANCER, Lyon, France
22 Department of Pathology, CHUGA, INSERM U 1209, University of Grenobles Alpes, Institute of Advanced Biosciences (IAB), 38043, Grenoble, France
23 Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland
24 Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland
25 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
26 Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
27 Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
28 Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, Oslo, Norway
29 Department of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Germany
30 Department of Surgery, St. Vincent’s Hospital, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
31 Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
32 Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS—Istituto Nazionale Tumori, Milan, Italy
33 Thoracic Surgery Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
34 Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany
35 Department of Internal Medicine II, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany
36 Institute for Pathology Bad Berka, Bad Berka, Germany
37 Gastrointestinal Cancer Group Cologne, Center of Integrated Oncology Cologne–Bonn, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Department of Pathology, University Hospital Cologne, Cologne, Germany
38 Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck and the Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
39 Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
40 Department of Pathology, University Hospital Cologne, Cologne, Germany
41 Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, Cologne, Germany; Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO), Lyon, France
42 Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, Cologne, Germany; Department of Pathology, University Hospital Cologne, Cologne, Germany; German Cancer Research Center, German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
; Alexandrov, Ludmil B 4
; Seidel, Danila 1 ; Leenders, Frauke 1 ; Maas, Lukas 1 ; Müller, Christian 1 ; Dahmen, Ilona 1 ; Delhomme, Tiffany M 5 ; Ardin, Maude 6 ; Leblay, Noemie 5 ; Byrnes, Graham 7 ; Sun, Ruping 8
; De Reynies, Aurélien 9 ; McLeer-Florin, Anne 10 ; Bosco, Graziella 1 ; Malchers, Florian 1 ; Menon, Roopika 11 ; Altmüller, Janine 12 ; Becker, Christian 13 ; Nürnberg, Peter 14 ; Achter, Viktor 15 ; Lang, Ulrich 16 ; Schneider, Peter M 17
; Bogus, Magdalena 17 ; Soloway, Matthew G 18 ; Wilkerson, Matthew D 19 ; Cun, Yupeng 3
; McKay, James D 5 ; Moro-Sibilot, Denis 20 ; Brambilla, Christian G 20 ; Lantuejoul, Sylvie 21 ; Lemaitre, Nicolas 22 ; Soltermann, Alex 23 ; Weder, Walter 24 ; Tischler, Verena 23 ; Brustugun, Odd Terje 25 ; Lund-Iversen, Marius 26 ; Helland, Åslaug 27 ; Solberg, Steinar 28 ; Ansén, Sascha 29 ; Wright, Gavin 30
; Solomon, Benjamin 31 ; Luca Roz 32 ; Pastorino, Ugo 33 ; Petersen, Iver 34 ; Clement, Joachim H 35 ; Sänger, Jörg 36 ; Wolf, Jürgen 29 ; Vingron, Martin 8
; Zander, Thomas 37 ; Perner, Sven 38 ; Travis, William D 39 ; Haas, Stefan A 8 ; Olivier, Magali 6 ; Foll, Matthieu 5 ; Büttner, Reinhard 40 ; Hayes, David Neil 18 ; Brambilla, Elisabeth 22 ; Fernandez-Cuesta, Lynnette 41 ; Thomas, Roman K 42 1 Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, Cologne, Germany
2 UNC Lineberger Comprehensive Cancer Center School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Biochemistry and Molecular Biology, Penn State Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, USA
3 Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
4 Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego, CA, USA
5 Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO), Lyon, France
6 Molecular Mechanisms and Biomarkers Group, Section of Mechanisms of Carcinogenesis, International Agency for Research on Cancer (IARC-WHO), Lyon, France
7 Section of Environment and Radiation, International Agency for Research on Cancer (IARC-WHO), Lyon, France
8 Computational Molecular Biology Group, Max Planck Institute for Molecular Genetics, Berlin, Germany
9 Programme Cartes d’Identité des Tumeurs (CIT), Ligue Nationale Contre le Cancer, Paris, France
10 CHU Grenoble Alpes, UGA/INSERM U1209/CNRS, Grenoble, France
11 NEO New Oncology GmbH, Cologne, Germany
12 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany; Institute of Human Genetics, University Hospital Cologne, Cologne, Germany
13 Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany
14 Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany; Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
15 Computing Center, University of Cologne, Cologne, Germany
16 Computing Center, University of Cologne, Cologne, Germany; Department of Informatics, University of Cologne, Cologne, Germany
17 Institute of Legal Medicine, University Hospital Cologne, Cologne, Germany
18 UNC Lineberger Comprehensive Cancer Center School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
19 Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, NC, USA
20 CHUGA Grenoble, INSERM U 1209, University Grenoble Alpes, Institute of Advanced Biosciences (IAB), 38043, Grenoble, France
21 Department of Pathology, CHUGA, INSERM U 1209, University of Grenobles Alpes, Institute of Advanced Biosciences (IAB), 38043, Grenoble, France; Department of Biopathology, Centre Léon Bérard UNICANCER, Lyon, France
22 Department of Pathology, CHUGA, INSERM U 1209, University of Grenobles Alpes, Institute of Advanced Biosciences (IAB), 38043, Grenoble, France
23 Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland
24 Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland
25 Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
26 Department of Pathology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
27 Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
28 Department of Thoracic Surgery, Rikshospitalet, Oslo University Hospital, Oslo, Norway
29 Department of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Germany
30 Department of Surgery, St. Vincent’s Hospital, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
31 Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
32 Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS—Istituto Nazionale Tumori, Milan, Italy
33 Thoracic Surgery Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
34 Institute of Pathology, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany
35 Department of Internal Medicine II, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany
36 Institute for Pathology Bad Berka, Bad Berka, Germany
37 Gastrointestinal Cancer Group Cologne, Center of Integrated Oncology Cologne–Bonn, Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany; Department of Pathology, University Hospital Cologne, Cologne, Germany
38 Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck and the Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany
39 Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
40 Department of Pathology, University Hospital Cologne, Cologne, Germany
41 Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, Cologne, Germany; Genetic Cancer Susceptibility Group, Section of Genetics, International Agency for Research on Cancer (IARC-WHO), Lyon, France
42 Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, Cologne, Germany; Department of Pathology, University Hospital Cologne, Cologne, Germany; German Cancer Research Center, German Cancer Consortium (DKTK), 69120 Heidelberg, Germany
Pages
1-13
Publication year
2018
Publication date
Mar 2018
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2013631083
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.