Content area
Full Text
About the Authors:
Céline Adam
Roles Investigation, Visualization, Writing - review & editing
Affiliations Institut Curie, PSL Research University, CNRS, UMR3244, Paris, France, Université Pierre et Marie Curie (UPMC), Paris, France
Raphaël Guérois
Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing - review & editing
Affiliation: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France
Anna Citarella
Roles Investigation, Visualization
Affiliations Institut Curie, PSL Research University, CNRS, UMR3244, Paris, France, Université Pierre et Marie Curie (UPMC), Paris, France
Laura Verardi
Roles Investigation
Affiliations Institut Curie, PSL Research University, CNRS, UMR3244, Paris, France, Université Pierre et Marie Curie (UPMC), Paris, France
Florine Adolphe
Roles Investigation
Affiliations Institut Curie, PSL Research University, CNRS, UMR3244, Paris, France, Université Pierre et Marie Curie (UPMC), Paris, France
Claire Béneut
Roles Investigation
Affiliations Institut Curie, PSL Research University, CNRS, UMR3244, Paris, France, Université Pierre et Marie Curie (UPMC), Paris, France
Vérane Sommermeyer
Roles Investigation
Affiliations Institut Curie, PSL Research University, CNRS, UMR3244, Paris, France, Université Pierre et Marie Curie (UPMC), Paris, France
Claire Ramus
Roles Investigation
Affiliation: Univ. Grenoble Alpes, CEA, INSERM, BIG-BGE, Grenoble, France
ORCID http://orcid.org/0000-0001-5578-8120
Jérôme Govin
Roles Funding acquisition, Investigation, Methodology, Supervision, Writing - review & editing
Affiliation: Univ. Grenoble Alpes, CEA, INSERM, BIG-BGE, Grenoble, France
ORCID http://orcid.org/0000-0001-5511-6965
Yohann Couté
Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing - review & editing
Affiliation: Univ. Grenoble Alpes, CEA, INSERM, BIG-BGE, Grenoble, France
Valérie Borde
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing - original draft, Writing - review & editing
* E-mail: [email protected]
Affiliations Institut Curie, PSL Research University, CNRS, UMR3244, Paris, France, Université Pierre et Marie Curie (UPMC), Paris, France
ORCID http://orcid.org/0000-0001-6520-2461Abstract
Histone H3K4 methylation is a feature of meiotic recombination hotspots shared by many organisms including plants and mammals. Meiotic recombination is initiated by programmed double-strand break (DSB) formation that in budding yeast takes place in gene promoters and is promoted by histone H3K4 di/trimethylation. This histone modification is recognized by Spp1, a PHD finger containing protein that belongs to the conserved histone H3K4 methyltransferase Set1 complex. During meiosis, Spp1 binds H3K4me3 and interacts with a DSB protein, Mer2, to promote DSB formation close to gene promoters. How Set1 complex- and...