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About the Authors:
Ilona Patursky-Polischuk
Current address: Orgenics Ltd, Yavne, Israel
Affiliation: Department of Biochemistry and Molecular Biology, The Institute for Medical Research – Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Judith Kasir
Affiliation: Department of Biochemistry and Molecular Biology, The Institute for Medical Research – Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Rachel Miloslavski
Affiliation: Department of Biochemistry and Molecular Biology, The Institute for Medical Research – Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Zvi Hayouka
Current address: Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
Affiliation: Department of Biochemistry and Molecular Biology, The Institute for Medical Research – Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Mirit Hausner-Hanochi
Current address: Pediatric Endocrinology Unit, Division of Pediatrics, Chaim Sheba Medical Center, Tel-Hashomer, Israel
Affiliation: Department of Biochemistry and Molecular Biology, The Institute for Medical Research – Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Miri Stolovich-Rain
Current address: Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Affiliation: Department of Biochemistry and Molecular Biology, The Institute for Medical Research – Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Pinchas Tsukerman
Affiliation: Lautenberg Center for General and Tumor Immunology, The Institute for Medical Research – Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Moshe Biton
Affiliation: Lautenberg Center for General and Tumor Immunology, The Institute for Medical Research – Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Rajini Mudhasani
Current address: United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
Affiliation: Department of Cell Biology, University of Massachusetts Medical School, North Worcester, Massachusetts, United States of America
Stephen N. Jones
Affiliation: Department of Cell Biology, University of Massachusetts Medical School, North Worcester, Massachusetts, United States of America
Oded Meyuhas
* E-mail: [email protected]
Affiliation: Department of Biochemistry and Molecular Biology, The Institute for Medical Research – Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel
Introduction
TOP mRNAs encode more than ninety proteins of the translational apparatus and are characterized by the presence of an oligopyrimidine tract at their 5′ terminus (5′TOP motif), which comprises their core translation cis-regulatory element [1]. The translation of these mRNAs is...