Abstract

Restoration of hard tissue in conjunction with adhesive is a globally challenging issue in medicine and dentistry. Common clinical therapies involving application of adhesive and substitute material for functional or anatomical recovery are still suboptimal. Biomaterials with bioactivity and inhibitory effects of enzyme-mediated adhesive degradation can render a solution to this. Here, we designed a novel copper-doped bioactive glass nanoparticles (CuBGn) to offer multifunction: metalloproteinases (MMP) deactivation and remineralization and incorporated the CuBGn in resin-dentin adhesive systems, which showed most common failure of MMP mediated adhesive degradation among hard tissue adhesives, to evaluate proposed therapeutic effects. A sol-gel derived bioactive glass nanoparticles doping 10 wt% of Cu (Cu-BGn) for releasing Cu ions, which were well-known MMP deactivator, were successfully created and included in light-curing dental adhesive (DA), a filler-free co-monomer resin blend, at different concentrations (up to 2 wt%). These therapeutic adhesives (CuBGn-DA) showed enhanced (a)cellular bioactivity, cytocompatibility, microtensile bond strength and MMP deactivation-ability. In conclusion, the incorporation of Cu ions releasing nano-bioactive glass demonstrated multifunctional properties at the resin-dentin interface; MMP deactivation and remineralization, representing a suitable strategy to extend the longevity of adhesive-hard tissue (i.e. resin-dentin) interfaces.

Details

Title
Multi-functional nano-adhesive releasing therapeutic ions for MMP-deactivation and remineralization
Author
Soo-Kyung, Jun 1 ; Sun-A, Yang 2 ; You-Jin, Kim 3 ; El-Fiqi, Ahmed 4 ; Mandakhbayar, Nandin 5 ; Duck-Su, Kim 6 ; Roh, Jiyeon 7   VIAFID ORCID Logo  ; Sauro, Salvatore 8   VIAFID ORCID Logo  ; Hae-Won, Kim 9 ; Jung-Hwan, Lee 10   VIAFID ORCID Logo  ; Lee, Hae-Hyoung 10   VIAFID ORCID Logo 

1  Department of Dental Hygiene, Kyungdong University, Wonju 26495, South Korea; Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan 31116, South Korea; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, South Korea 
2  Lithuanian University of health sciences, Kaunas, Lithuania 
3  Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan 31116, South Korea 
4  Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, South Korea; Glass Research Department, National Research centre, Cairo, Egypt 
5  Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, South Korea 
6  Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul, South Korea 
7  Department of Dental Hygiene, Yonsei University Wonju College of Medicine, Wonju, South Korea 
8  Dental Biomaterials, Departamento de Odontología, Facultad de Ciencias de la Salud, University CEU-Cardenal Herrera, Valencia, Spain; Tissue Engineering & Biophotonics, King’s College London Dental Institute (KCLDI), London, UK 
9  Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan 31116, South Korea; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, South Korea; Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine Research Center, Dankook University, Cheonan, South Korea 
10  Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan 31116, South Korea; Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, South Korea 
Pages
1-10
Publication year
2018
Publication date
Apr 2018
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-018-23939-6
ProQuest document ID
2021753604
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.