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Received Mar 7, 2018; Accepted Mar 7, 2018
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Oxidative stress is a common aetiological factor in aging, metabolic diseases, and degenerative disorders. The body contains an endogenous antioxidant system to help neutralize reactive oxygen species and mitigate oxidative damage. Every living cell survives when there is a balance between the oxidative stress generated and the counter antioxidant system present. Once this harmony is disrupted, the generated stress loads on the cell and starts to exert pathological, metabolic, and degenerative effects. Antioxidants have been proven to ameliorate drug toxicity [1], carcinogenesis [2], and neurodegenerative processes [3, 4]. In this special issue, several articles have proposed different molecular mechanisms to mitigate oxidative stress and prevent aging, metabolic, and degenerative disorders.
For example, S. M. Ahmed et al. searched and analyzed previous animal studies to develop a conclusive systematic review discussing the use of different types of mesenchymal stromal cells (MSCs) for the treatment of acute and chronic pancreatitis and pancreatic fibrosis. They concluded that bone marrow and umbilical cord MSCs were the most frequently administered cell types. In addition, they did not...