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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in therapy due to their anti-inflammatory and analgesic properties. However, their clinical use is often associated with gastrointestinal complications. Thus, this study aimed to investigate the protective effect of a sulfated iota-carrageenan isolated from the marine alga Solieria filiformis (IC-Sf) against naproxen-induced gastrointestinal injury. Methods: Parameters of gastrointestinal injury, secretory and motor functions, and toxicity were evaluated. Results: The results demonstrated that IC-Sf significantly reduced naproxen-induced gastrointestinal macroscopic injury, with a maximum effect observed at 30 mg/kg. IC-Sf also preserved gastrointestinal antioxidant defense and prevented lipid peroxidation, with a reduction in the non-protein sulfhydryl group (NP-SH) and malondialdehyde (MDA) concentrations induced by naproxen. Additionally, IC-Sf mitigated naproxen-induced gastrointestinal inflammation, as evidenced by reduced myeloperoxidase (MPO) activity, tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β). IC-Sf did not alter gastric secretion or gastrointestinal motility. In addition, the animals treated with IC-Sf did not present toxic effects. Conclusions: In conclusion, IC-Sf protected the gastrointestinal tract against the harmful effects of naproxen by inhibiting the inflammatory response and lipid peroxidation, suggesting its potential as a new therapeutic agent or food additive.

Details

Title
Iota-Carrageenan from Marine Alga Solieria filiformis Prevents Naproxen-Induced Gastrointestinal Injury via Its Antioxidant and Anti-Inflammatory Activities
Author
Pinheiro, João L S 1 ; Sousa, Willer M 2 ; Rodrigues, Lucas H M 1 ; Bezerra, Francisco F 2 ; Cecília L O A Cunha 1 ; Santos, Victória M R 1 ; Samara R B D Oliveira 3 ; Bingana, Rudy D 3 ; Barbosa, André Luiz R 4   VIAFID ORCID Logo  ; Marcellus H L P Souza 3 ; Freitas, Ana Lúcia P 2 ; Damasceno, Renan O S 1 

 Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife 50670-420, PE, Brazil; [email protected] (J.L.S.P.); [email protected] (L.H.M.R.); [email protected] (C.L.O.A.C.); [email protected] (V.M.R.S.) 
 Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza 60020-181, CE, Brazil; [email protected] (W.M.S.); [email protected] (F.F.B.); [email protected] (A.L.P.F.) 
 Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza 60430-275, CE, Brazil; [email protected] (S.R.B.D.O.); [email protected] (R.D.B.); [email protected] (M.H.L.P.S.) 
 Department of Physiotherapy, Parnaíba Delta Federal University, Parnaíba 64202-020, PI, Brazil; [email protected] 
First page
2574
Publication year
2024
Publication date
2024
Publisher
MDPI AG
e-ISSN
22279059
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
3132933431
Copyright
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.