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The dye FD&C Blue No. 1 (Blue 1; triphenylmethane) is sometimes added to enteral feeding solutions of critically ill patients to detect pulmonary aspiration. However, serious outcomes have been reported in some patients undergoing such tests. The FDA recently issued a warning that the test may result in rare but serious toxic effects, including blue-green discoloration of the skin and bodily fluids, refractory hypotension, metabolic acidosis and death.3
Blue 1 is a water-soluble dye used in a variety...